Abstract：Objective To explore the efficacy of esophageal vein ligation combined with endoscopic injection sclerotherapy sequential treatment of esophageal variceal bleeding in cirrhosis.Methods Fifty-seven patients with cirrhosis and esophageal variceal bleeding after twice esophageal variceal ligation, whose endoscopic grade of esophageal varices was still moderate (G2) and severe (G3), were selected between April 2014 and April 2017 as the subjects.Using the random number table method, these patients were divided into the control group of 28 cases and the study group of 29 cases. The study group was treated with EIS sequential therapy,while the control group continued to be treated with EVL sequential therapy. Both groups were followed up for one year after treatment and results of gastroscopy were reviewed. The number of times of sequential treatment、rate esophageal varice eradication, incidence of rebleeding, and incidence of complications were compared between the two groups.Results Sequential treatment was less frequent in the study group (2.24±0.95) than in the control group (3.29 ±1.27). The rate of esophageal varice eradication was(89.66%) in the study group, which was significantly better than that of the control group(46.43%), and the rate of rebleeding(2.45%) was lower than that of the control group (P<0.05). There was no statistically significant difference in the incidence of complications between the two groups (P>0.05).Conclusions EVL and EIS sequential therapy in the treatment of cirrhosis with esophageal variceal bleeding can effectively reduce the frequency of endoscopic treatment, mitigate residual esophageal varices after ligation, delay the recurrence of varicose veins, and without any increased risk of complications.
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Marmo R, Piano M D, Cipolletta L, et al. 1039 Mortality From Non Variceal Upper Gastrointestinal Bleeding in Patients With Liver Cirrhosis: an Individual Patient Data Meta-Analysis[J]. Gastrointestinal Endoscopy, 2013, 77(5):AB180-AB180.
2018, Vol. 29 
