Association of OPRM1 polymorphisms with depressive disorder in northern Han Chinese Populations
MA Xinhui1,SUN Haixin1,DU Jinzhan2,FU Yu1,and LIU Chenyang1
1.Department of Clinical Laboratory,Heilongjiang Provincial Corps Hospital, Chinese People’s Armed Police Force,Harbin 150076, China;
2.The Third Medical Center of the General Hospital of the Chinese People’s Liberation Army,Beijing 100039, China
Objective To investigate the pharmacodynamics of Mμ-Opioid receptor gene(OPRM1)as a candidate gene to obtain the data on genetic polymorphisms for the study of depression pathogenesis, genetic diagnosis and treatment.Methods Genomic DNA was isolated from the venous blood leukocytes of 393 unrelated patients with depressive disorder and 738 unrelated healthy servicemen.All the polymorphisms were genotyped by PCR-restriction fragment length polymorphisms (PCR-RFLP)and polymerase chain reaction-sequence specific primer(PCR-SSP).Genotypes and allele frequencies were analyzed with SPSS13.0 software and Haploview software.Results There was significant difference in both allele and genotype frequencies of OPRM1 genes between the depressive disorder group and control group(P<0.05).The allele T of rs1799971C/T in the male depressive disorder group aged 34 to 49 was significantly higher than that in the control group(OR=0.564,95%CI:0.196-0.837,P=0.001) The allele A of rs648893G/A was not significantly different between the depressive disorder group and the control group(OR=0.853,95%CI:0.649-1.121,P=0.139).Conclusions OPRM1genes are associated with depressive disorder with exon1 T allele of rs1799971.The OPRM1 gene is susceptible to depressive disorder in northern Han Chinese populations.
马心慧,孙海昕,杜金赞,付瑜,刘晨阳. 中国北方抑郁症与OPRM1基因多态性的相关性研究[J]. 武警医学, 2019, 30(2): 116-119.
MA Xinhui,SUN Haixin,DU Jinzhan,FU Yu,and LIU Chenyang. Association of OPRM1 polymorphisms with depressive disorder in northern Han Chinese Populations. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(2): 116-119.
Saidan Ding,Bicheng Chen,Yong Zheng,et al. Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population[J]. BMC Psychiatry ,2013, 13(2):107-117.
2019, Vol. 30 
