Abstract：Objective To explore the non-single network correlations between multiple components,targets, and pathways of Congrong Yishen granules(CYGs) in the treatment of diabetic nephropathy (DN) via network pharmacology in order to predict the potential mechanism of action.Methods TCMSP and other online databases were searched for the active components of CYGs and the relevant targets on DN before they were screened. The screened targets were submitted to STRING and Cytoscape tools for network visualization. KEGG enrichment analysis of the core targets was performed with ClueGO plugin to predict the potential mechanism of CYGs against DN.Results A total of 69 active components and 37 core targets against DN were screened from CYGs. After enrichment analysis, 94 significantly related signaling pathways were identified, including the AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, fluid shear stress and atherosclerosis, involving 352 significantly related biological processes including response to lipopolysaccharide, response to reactive oxygen species, and cell proliferation.Conclusions CongRong YiShen granules may contribute to the treatment of DN by intervening in the AGE-RAGE signaling pathway and TNF signaling pathway in the human body through AKT1, IL-6, TNF, VEGFA and other key targets before participating in such biological processes as inflammatory response, response to reactive oxygen species and oxidative stress.
蔡文玺, 李浩, 石磊, 张磊. 苁蓉益肾颗粒治疗糖尿病肾病的潜在作用机制[J]. 武警医学, 2020, 31(10): 829-833.
CAI Wenxi, LI Hao, SHI Lei, ZHANG Lei. The poterrtial mechanism of Congrong Yishen granules in the treatment of diabetic mephropathy. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(10): 829-833.
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