Abstract：Objective To investigate the consistency between the results of fecal occult blood test and helicobacter pylori antigen test detected by KU-F20, AVE-562 and FA280 stool analyzers and those of manual detection. Methods A total of 1851 fecal samples from inpatients were collected between June and September 2020. The fecal occult blood and helicobacter pylori antigens were detected by automatic stool analyzers and manually respectively. The sensitivity, specificity and coincidence rate of each instrument were calculated, while the difference and consistency were analyzed. Results Compared with manual detection, the sensitivity of Ku-F20, AVE-562 and FA280 fecal occult blood detection was 0.96, 0.91 and 0.99 respectively, the specificity was 0.75, 0.84 and 0.63 respectively, the coincidence rate was 0.91, 0.89 and 0.92 respectively, the paired chi-square test was P=0.424, 0.099, <0.01, and the Kappa values were 0.73, 0.71 and 0.71 respectively. The sensitivity of Ku-F20, AVE-562 and FA280 for helicobacter pylori detection was 0.88, 0.85 and 0.90 respectively, the specificity was 0.60, 0.95 and 0.66 respectively, the coincidence rate was 0.80, 0.88 and 0.83 respectively, the paired chi-square test was P=0.689, <0.01, 0.56, and the Kappa values were 0.48, 0.73 and 0.56 respectively. Conclusions The consistency of the three stool analyzers with manual detection in detecting fecal occult blood is significant, so is the consistency between AVE-562 and manual detection in detecting fecal helicobacter pylori antigens.
薛丹丹, 任爽, 方乾坤, 马骏龙, 王成彬. 三种全自动粪便分析仪对粪便隐血和幽门螺杆菌抗原检测的效果比较[J]. 武警医学, 2021, 32(11): 929-932.
XUE Dan, REN Shuang, FANG Qiankun, MA Junlong, WANG Chengbin. Comparison of three automatic stool analyzers in the detection of fecal occults and helicobacter pylori antigen. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(11): 929-932.
Ignatius R, Berg C, Weiland C, et al. Accurate detection of helicobacter pylori antigen in human stool specimens by two novel immunoassays[J]. Eur J Microbiol Immunol, 2019, 9 (2): 29-31.
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68 (6):394-424.
[8]
Yu W, Jiang J, Xie L, et al. Mortality trends in colorectal cancer in China during 2000-2015: a joinpoint regression and age-period-cohort analysis[J]. Prev Chronic Dis, 2018, 15:180329.
Gravina A G, Zagari R M, Musis C, et al. Helicobacter phlori and extragastric diseases:a review[J]. World J Gastroenterol, 2018, 24(29):3204-3221.
[15]
Zamani M, Ebrahimtabar F, Zamani V, et al. Systematic review with meta-analysis:the worldwide prevalence of helicobacter pylori infection[J]. Aliment Pharmacol Ther, 2018, 47(7):868-876.
[16]
Kalach N, Gosset P, Dehecq E, et al. A one-step immune-chroma-tographic helicobacter pylori stool antigen test for children was quick, consistent, reliable and specific[J]. Acta Paediatr, 2017, 106(12):2025-2030.
2021, Vol. 32 
