Abstract：Objective To investigate the safety and effectiveness of bladder hydrodistention combined with intravesical instillation of three drugs (heparin, lidocaine and sodium bicarbonate) in the treatment of patients with interstitial cystitis/bladder pain syndrome. Methods The clinical data of 25 patients who had undergone bladder hydrodistention under general anesthesia between January 2014 and February 2019 in the Department of Urology was retrospectively analyzed. Intravesical instillation of three-drug combination (low-molecular-weight heparin aodium for injection 40,000 u , 2% lidocaine 10ml, and 5% sodium bicarbonate 10ml ) was administered once per week for 8 weeks, and then once a month. The interstitial cystitis symptom index, interstitial cystitis problem index (O'Leary-Sant problem index), visual analog score for pain, voiding frequency, bladder capacity, and side effects were recorded. Results At 1, 3, 6 and 12 months after treatment, the remission rate was 92%,88%,80% and 60% respectively. The O'Leary-Sant symptom index, O'Leary-Sant problem index, voiding frequency and pain score were improved after treatment(P<0.01). The maximum bladder capacity improved at 1,3 and 6 months, and was reduced to the pretreatment level at 12 months. No significant adverse reactions occurred in any of the patients. Conclusions Bladder hydrodistention combined with intravesical instillation of three drugs for bladder pain syndrome and interstitial cystitis is safe and effective, which can significantly reduce clinical symptoms and improve the quality of life of patients.
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2021, Vol. 32 
