Abstract：Objective To determine the efficacy of modafinil for cognitive enhancement in healthy adults by means of literature retrieval and meta-analysis. Methods Such databases as Pubmed, Web of Science and Cochrane Library were extensively searched. Eligible randomized clinical trials that evaluated the efficacy of modafinil versus placebo for cognitive function in healthy adults were included and analyzed by using RevMan5.4. Results A total of 14 trials involving 7 crossover studies(n=248) and 7 parallel studies(n=328, 143 of the cases received modafinil and 185 received placebo) were included in the final analysis. Generic inverse variance meta-analysis indicated that there was statistically significant difference in the overall effect between modafinil and placebo(SMD=0.11, 95%CI=0.02-0.21,Z=2.46,P=0.01,I2= 70%). Subgroup analysis did not indicate significant difference in cognitive function tests between different groups. Conclusions Modafinil can help improve cognition to some extent. Because of the limited evidence available, further studies are needed to elucidate the applicability of modafinil as a “smart” drug.
陶天柱, 王昳, 徐余海, 张国荣, 邓略, 刘珺, 杨晓明. 莫达非尼改善健康成年人认知功能的Meta分析[J]. 武警医学, 2022, 33(1): 22-26.
TAO Tianzhu, WANG Yi, XU Yuhai, ZHANG Guorong, DENG Lve, LIU Jun, YANG Xiaoming. Efficacy of modafinil for cognitive enhancement in healthy adults: a meta-analysis. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(1): 22-26.
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