Meta-analysis of clinical efficacy of glutamine in treatment of severe burn in adults
LIU Shujing1, YU Yingying2, WANG Yu1, LIU Lifang1, XIE Rong1, TANG Qiuxiang1, WANG Hao3
1. Department of Burn and Plastic Surgery, the 921th Hospital of Chinese PLA, Changsha 410005, China; 2. Pharmacy Department, Hunan Provincial Corps Hospital of Chinese People’s Armed Police Force, Changsha 410006, China; 3. Sports Medicine Department, Characteristics Medical Center of Chinese People’s Armed Police Force, Tianjin 300162, China
Abstract：Objective To evaluate the clinical efficacy of glutamine on adult patients with severe burn by meta-analysis. Methods Randomized controlled clinical trials of glutamine for severe burn of adult patients were retrieved from PubMed, Embase, Cochrane Library, China HowNet, Wanfang HowNet, and Baidu Academic databases. Meta-analysis was performed using RevMan 5.3 software after strict quality evaluation. Clinical indicators were mortality, infection rate, length of hospital stay and intensive care unit (ICU) treatment time. Results A total of 11 randomized controlled trials (RCTs) were included, involving a total of 1620 patients. Compared with the control group, there were no statistically significant differences in mortality (RR=0.95, 95% CI, 0.74- 1.23; P=0.72), hospital infection rate (RR=0.94, 95% CI, 0.77-1.14; P=0.51), or intensive care unit (ICU) treatment time (MD=-1.85 d; 95% CI, -6.31-2.60 d; P=0.41) between the glutamine treatment group and the control group, but mean length of hospital stay in the glutamine treatment group was less than that in the control group (MD=4.77 d; 95% CI, -9.43- -0.12 d; P=0.04), the difference was statistically significant. Conclusions The use of glutamine in the treatment of adult patients with severe burn can shorten the average hospitalization stay, but there is no significant advantage in reducing mortality, infection rate, or intensive care unit (ICU) treatment time, so it is recommended to use it with caution in clinical practice.
刘数敬, 喻瑛瑛, 王宇, 刘丽芳, 谢蓉, 唐秋香, 王昊. 谷氨酰胺治疗成人严重烧伤临床疗效的Meta分析[J]. 武警医学, 2023, 34(11): 954-959.
LIU Shujing, YU Yingying, WANG Yu, LIU Lifang, XIE Rong, TANG Qiuxiang, WANG Hao. Meta-analysis of clinical efficacy of glutamine in treatment of severe burn in adults. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(11): 954-959.
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