NT-proBNP与可溶性ST2评估妊娠合并心脏病患者心功能的价值

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摘要目的探讨氨基端前脑钠素(NT-proBNP)和可溶性生长刺激表达基因2蛋白(sST2)浓度评估妊娠合并心脏病患者心功能的价值。方法选择2017-01至2021-12在北部战区总医院妇产科住院的228例妊娠合并心脏病患者资料,检测不同类型妊娠合并心脏病患者NT-proBNP和可溶性ST2浓度,使用SPSS21.0统计学软件进行数据分析。结果 (1)以先天性心脏病为主要症状的妊娠合并心脏病患者145例,占63.6%,其次症状为心律失常(78例,34.2%),其他(5例,2.2%);(2)将患者按照心功能Ⅰ、Ⅱ、Ⅲ~Ⅳ级分组,比较其入院时血浆NT-proBNP和可溶性ST2浓度,发现NT-proBNP和可溶性ST2浓度Ⅰ级组和Ⅱ级组分别与Ⅲ～Ⅳ级组间差异有统计学意义(P＜0.05),但Ⅰ级组与Ⅱ级组组间NT-proBNP浓度差异无统计学意义(P＞0.05),可溶性ST2浓度差异有统计学意义(P＜0.05);(3)先天性心脏病组和心律失常组比较入院血浆NT-proBNP浓度和可溶性ST2浓度,Ⅰ级组的NT-proBNP浓度、可溶性ST2浓度差异无统计学意义(P＞0.05),Ⅱ级组的NT-proBNP浓度差异无统计学意义(P＞0.05)。而Ⅱ级组的可溶性ST2浓度差异有统计学意义(P＜0.05),Ⅲ~Ⅳ级组的NT-proBNP浓度、可溶性ST2浓度差异有统计学意义(P＜0.05)。结论血浆NT-proBNP和可溶性ST2浓度在评估妊娠合并心脏病患者心功能时有十分重要的价值。可溶性ST2浓度与心功能分级和心肌损伤程度相关性良好,且特异性较强。

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	洪岩
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关键词 ：妊娠合并心脏病, NT-proBNP, 可溶性ST2, 意义

Abstract：Objective To analyze the value of NT- proBNP and soluble ST2 in the evaluation of cardiac function in pregnant women with heart disease. Methods Data analysis was performed on 228 patients with heart disease who were hospitalized in the obstetrics ward and gynecology department of the General Hospital of PLA Northern Theater from January 2017 to December 2021 by SPSS21.0 statistical software. Results Congenital heart disease was the main symptom in 145 cases, accounting for 63.6%, followed by arrhythmia (78 cases, 34.2%) and others (5 cases, 2.2%);The patients were divided into groups according to cardiac function grades Ⅰ, Ⅱ, Ⅲ and Ⅳ, and the plasma NT-proBNP and soluble ST2 concentrations were compared at admission. It was found that the concentration of NT-proBNP and soluble ST2 in grade Ⅰ and grade Ⅱ groups was significantly different from that in groups of grade Ⅲ to Ⅳ, respectively (P<0.05). However, there was no significant difference in the concentration of NT-proBNP between group Ⅰ and group Ⅱ (P>0.05), and there was significant difference in the concentration of soluble ST2 between group Ⅰ and group Ⅱ (P<0.05). The concentration of NT-proBNP and soluble ST2 in plasma was compared between congenital heart disease group and arrhythmia group. There was no statistically significant difference in the concentration of NT proBNP and soluble ST2 in the grade I group (P>0.05), and no statistically significant difference in the concentration of NT proBNP in the grade Ⅱ group (P>0.05). The concentration of soluble ST2 in grade Ⅱ group was statistically significant (P<0.05), and the concentration of NT-proBNP and soluble ST2 between the grade Ⅲ-Ⅳ groups was statistically significant (P<0.05). Conclusions The concentration of plasma NT proBNP and soluble ST2 is of great value in assessing cardiac function in pregnant patients with cardiac disease. The concentration of soluble ST2 has a close correlation with cardiac functional grades and the degree of heart failure, and the specificity is strong.

Key words： pregnancy with heart disease NT-proBNP soluble ST2 significance

收稿日期: 2022-12-16

ZTFLH:

R71

基金资助:辽宁省科学技术计划项目(2021JH2/10300095)

通讯作者: 李鸿飞,E-mail:lihongfei-2008@163.com

作者简介: 洪岩,硕士,副主任医师。

引用本文:

洪岩, 曲冬颖, 李鸿飞. NT-proBNP与可溶性ST2评估妊娠合并心脏病患者心功能的价值[J]. 武警医学, 2023, 34(12): 1042-1045. HONG Yan, QV Dongying, LI Hongfei. Value of NT proBNP and soluble ST2 in evaluating cardiac function in pregnant women with heart disease. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(12): 1042-1045.

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http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2023/V34/I12/1042

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