Therapeutic effect of mindfulness training on chronic insomnia disorder patients and its impact on inflammatory factors
ZHANG Ying1, GE Lina1, CAO Lei2, ZOU Jie1, ZHOU Lei1
1. Department of Medical Psychology, 2. Rehabilitation Medicine and Physical Therapy, Jilin Provincial Corps Hospital of Chinese People's Armed Police Force, Changchun 130052,China
Abstract：Objective To explore the therapeutic effect of mindfulness training on chronic insomnia patients and its impact on inflammatory factors. Methods A total of 82 patients with chronic insomnia disorder (CID) diagnosed in Jilin Provincial Corps Hospital of Chinese People’s Armed Police Force from February 2022 to May 2023 were selected and divided into observation group (41 cases) and control group (41 cases).The control group received extropiclone tablet orally, and the observation group received dextropiclone tablet combined with mindfulness training therapy. The two groups were treated for 5 weeks. The total effective rate, the changes of Pittsburgh Sleep index (PSQI) and insomnia severity index (ISI) before and after treatment, depression and anxiety status and the changes of inflammatory factors were compared between the two groups. Result The total effective rate of the observation group(90.24%) was higher than that of the control group (70.73%), and the difference was significant(χ2=4.970,P=0.026). After treatment, the scores of PSQI and ISI scales in 2 groups were lower than those before treatment (P<0.05). The scores of the two scales after treatment in the observation group were lower than those in the control group (P<0.05). After treatment, the scores of Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) in 2 groups were lower than before treatment (P<0.05). The scores of the two scales after treatment in the observation group were lower than those in the control group (P<0.05).After treatment, the serum levels of interleukin-1β and tumor necrosis factor (TNF) -α in 2 groups were lower than those before treatment (P<0.05); After treatment, the levels of IL-1β and TNF-α in the observation group were lower than those in the control group (P<0.05). Conclusions Mindfulness training can improve the treatment effect of patients with chronic insomnia disorder, improve the sleep quality of patients and reduce the inflammatory response of patients.
张颖, 葛丽娜, 曹雷, 邹杰, 周磊. 正念训练对慢性失眠障碍患者治疗效果及炎症因子的影响[J]. 武警医学, 2024, 35(1): 30-33.
ZHANG Ying, GE Lina, CAO Lei, ZOU Jie, ZHOU Lei. Therapeutic effect of mindfulness training on chronic insomnia disorder patients and its impact on inflammatory factors. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(1): 30-33.
Silva L A S, Amaral M M, Grassi V, et al. Chronic insomnia disorder as risk factor for stroke: a systematic review[J]. Arq Neuropsiquiatr, 2022, 80(11):1159-1166.
[2]
Fietza I, Bassetti C L A, Mayleben D W, et al. Efficacy and safety of daridorexant in older and younger adults with insomnia disorder: a secondary analysis of a randomised placebo-controlled trial[J]. Drugs Aging, 2022, 39(10):795-810.
Morgenthaler T I, Kolla B P, Anderson S E, et al. Development and acceptability of a mobile health application integrated with the electronic heath record for treatment of chronic insomnia disorder[J]. J Clin Sleep Med, 2022, 18(12):2785-2792.
[10]
Gong L, He K W, Cheng F, et al. The role of ascending arousal network in patients with chronic insomnia disorder[J]. Hum Brain Mapp, 2023, 44(2):484-495.
2024, Vol. 35 
