Effects of remazolam besylate combined with sufentanil on hemodynamics and stress response in patients undergoing hysteroscopy surgery
YANG Yanjun1, JIAO Yan2, DUAN Feng1, LU Yiping1, HUAN Yingjing1, YANG Runnan3
1. Department of Outpatient, 2. Department of Anesthesiology, 3. Department of Medical Engineering, Henan Provincial Corps Hospital of Chinese People’s Armed Police Force, Zhengzhou 450052, China
Abstract：Objective To evaluate the effects of remazolam besylate anesthesia on hemodynamics and stress response in patients undergoing hysteroscopic surgery. Methods A total of 94 female patients undergoing hysteroscopic surgery were selected and divided into study group and control group by random number table method (n=47). The control group was given propofol combined with sufentanil, and the study group was given remazolam besylate combined with sufentanil. The hemodynamics, stress response indexes, pain and sedation, and the occurrence of adverse reactions were compared between the two groups. Results Heart rate (HR) and mean arterial pressure (MAP) of the two groups significantly decreased when the laryngeal mask was inserted (T1), cervical dilation (T2) and laryngeal mask was removed (T3) compared with that before anesthesia induction (T0) (P<0.05), and the blood oxygen saturation (SpO2) of the control group significantly decreased at T1 and T0 (P<0.05). HR and MAP of T1, T2 and T3 in the study group were significantly higher than those in the control group (P<0.05). Epinephrine (E), norepinephrine (NE) and cortisol (Cor) in both groups were significantly higher than those before surgery at 2 h, 12 h and 48 h after surgery (P<0.05), and E, NE and Cor in the study group were significantly lower than those in the control group (P<0.05). The resting VAS score of the study group was significantly lower than that of the control group at 2 h and 12 h after surgery (P<0.05), and the Ramsay score was significantly higher than that of the control group (P<0.05). The incidence of postoperative adverse reactions in the study group (6.38%) was significantly lower than that in the control group (29.79% ,P<0.05). Conclusions Compared with propofol combined with sufentanil, remazolam besylate combined with sufentanil has more stable hemodynamics, lower postoperative stress reaction and pain, good sedation effect and less adverse reactions in hysteroscopic surgery.
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2024, Vol. 35 
