Diagnostic value of CT feature analysis in atypical or early high-altitude pulmonary edema
YUE Lina1, NIU Juanqin1, CHEN Gang1, XUE Wei1, CHENG Manping1, FAN Jia1, LIU Kang1, LI Zhonghua2
1. Department of Radiology Diagnosis, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China; 2. Department of Medical Engineering, the 944th Hospital of PLA Joint Logistics Support Force, Jiuquan 735000, China
Abstract：Objective To evaluate the diagnostic value of CT features in atypical or early high-altitude pulmonary edema (HAPE). Methods The CT features of chest of 50 patients with early HAPE were analyzed retrospectively, and the diagnostic value of CT in early HAPE was summarized. Results Among the 50 cases, 35 cases involved unilateral lung and 15 cases involve bilateral lung, including 25 cases of right lung and 10 cases of left lung. Bilateral lung was involved in 15 cases. The lesions were localized in one lobe in 35 cases, in two lobes in 10 cases, and in three or more lobes in 5 cases. Early HAPE chest CT imaging features included increased and thickened bronchial-vascular bundles in both lungs, light ground-glass like changes, polygonal, quasi circular and small patchy high-density shadows, grid-like changes, nodule shadows in the lateral field of the lung, widened inner diameter of main pulmonary artery, thickened interlobular pleural, and compensatory emphysema. Conclusions Chest CT examination is one of the most important methods in the diagnosis of HAPE, which can significantly improve the diagnostic accuracy of early or atypical HAPE.
Khan M, Khan M, Bordes S, et al. Physiology,pulmonary vasoconstriction[J]. Treasure Island(FL), 2020, 1:1-25.
[12]
Dehnert C, Mereles D, Greiner S, et al. Exaggerated hypoxic pulmonary vasoconstriction without susceptibility to high altitude pulmonary edema[J]. High Alt MedBiol, 2015, 16(1): 11-17.
Sharma M, Singh S B, Sarkar S. Genome wide expression analysis suggests perturbation of vascular homeostasis during high altitude pulmonary edema[J]. PLoS One, 2014, 9(1): e85902.
[11]
Khan M, Khan M, Bordes S, et al. Physiology,pulmonary vasoconstriction[J]. Treasure Island(FL), 2020, 1:1-25.
[15]
Eichstaedt C A, Mairbäurl H,Song J,et al. Genetic Predisposition to High-Altitude Pulmonary Edema[J]. High Alt Med Biol, 2020, 21: 28-36.
[12]
Dehnert C, Mereles D, Greiner S, et al. Exaggerated hypoxic pulmonary vasoconstriction without susceptibility to high altitude pulmonary edema[J]. High Alt MedBiol, 2015, 16(1): 11-17.
[16]
Mulchrone A, Moulton H, Eldridge M W, et al. Susceptibility to high-altitude pulmonary edema is associated with increased pulmonary arterial stiffness during exercise[J]. J Appl Physiol, 2020,128:514-522.
[13]
Sartori C, Vollenweider L, Ffler B M, et al. Exaggerated endothelin releasein high-altitude pulmonary edema[J]. Circulation, 1999, 99(20): 2665-2668.
[17]
Korzeniewski K,Nitsch O A,Guzek A,et al. High altitude pulmonary edema in mountain climbers[J]. Respir Physiol Neurobiol, 2015, 209(5):33-38.
[14]
Sharma M, Singh S B, Sarkar S. Genome wide expression analysis suggests perturbation of vascular homeostasis during high altitude pulmonary edema[J]. PLoS One, 2014, 9(1): e85902.
[18]
Macinnis M J,Koehle M S,Rupert J L.Evidence for a genetic basis for altitudeillness:2010 update[J]. Highalt Med Biol, 2010, 11(4): 349-368.
[15]
Eichstaedt C A, Mairbäurl H,Song J,et al. Genetic Predisposition to High-Altitude Pulmonary Edema[J]. High Alt Med Biol, 2020, 21: 28-36.
[19]
Lorenzo V F, Yang Y, Simonson T S, et a1. Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation han Chinese family[J]. Blood Cells Mol Dis, 2009, 43(3): 221-225.
[16]
Mulchrone A, Moulton H, Eldridge M W, et al. Susceptibility to high-altitude pulmonary edema is associated with increased pulmonary arterial stiffness during exercise[J]. J Appl Physiol, 2020,128:514-522.
[20]
Wilkins M R, Ghofrani H A, Weissmann N, et al. Pathophysiology and treatmeng of high altitude pulmo-Nary vascular disease[J]. Circulation, 2015, 131(6): 582-590.
[17]
Korzeniewski K,Nitsch O A,Guzek A,et al. High altitude pulmonary edema in mountain climbers[J]. Respir Physiol Neurobiol, 2015, 209(5):33-38.
Macinnis M J,Koehle M S,Rupert J L.Evidence for a genetic basis for altitudeillness:2010 update[J]. Highalt Med Biol, 2010, 11(4): 349-368.
[19]
Lorenzo V F, Yang Y, Simonson T S, et a1. Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation han Chinese family[J]. Blood Cells Mol Dis, 2009, 43(3): 221-225.
[20]
Wilkins M R, Ghofrani H A, Weissmann N, et al. Pathophysiology and treatmeng of high altitude pulmo-Nary vascular disease[J]. Circulation, 2015, 131(6): 582-590.
2024, Vol. 35 
