Effect of intensive insulin therapy on βcell functions and inflammatory factor with newly diagnosed elderly overweight type 2 diabetes mellitus
ZENG Jian1, CHEN Xiaojun1,LI Yanmin2, HU Dandan2
1.First Department of Medicine, 2 No.3 Department of Medicine, Fujian Provincial Corps Hospital of Chinese People’s Armed Police Forces,Fuzhou 350003,China
Abstract：Objective To investigate the mechanism of effect of short term intensive insulin therapy on βcell functions with newly diagnosed elderly overweight type 2 diabetesmellitus. Methods 112 patients were divided into two groups. 60 patients received therapy of continuous subcutaneous insulin infusion(CSII). 52 patients accepted therapy of oral hypoglycaemic agents(OHA).All patients were tested plasma proinsulin(PI),immunoreactive insulin(IRI),high sensitivity C-reactive protein(hsCRP), tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6)before therapy and after therapy; homoeostasis model assessment basal β-cell function (HOMA B) and insulin resistance (HOMA-IR)were calculated. Results After therapy, HOMA B and HOMA-IR were significantly increased in two groups, compared with before therapy(P＜0.05). PI/IRI(ΔPI/IRI:7.5±1.4 vs 3.8±1.6) and inflammatory fator[ΔhsCRP: 0.9±0.4 vs 0.3±0.1(mg/L)、ΔTNF-α:1.1±0.4 vs 0.4±0.3(ng/L)、ΔIL-6:0.7±0.3 vs 0.4±0.2(ng/L)] were significantly decreased in CSII group after therapy(P＜0.05). Multiple linear regression analysis showed that the decrease in PI/IRI was positively correlated with the decrease in hsCRP,TNF-α and IL-6(P＜0.05). Conclusions The effect of short term intensive insulin therapy on βcell function with newly diagnosed elderly overweight type 2 diabetesmellitus is related to inflammation.
Johnson S L, McEwen L N, Newton C A. The impact of continuous subcutaneous insulin infusion and multiple daily injections of insulin on glucose variability in older adults with type 2 diabetes [J]. J Diabetes Complications,2011,25(4):211-215.
[3]
Calle M C, Fernandez M L. Inflammation and type 2 diabetes[J]. Diabetes Metab,2012,38(3):183-191.
[4]
Krystallenia Alexandraki, Christina Piperi, Christos Kalofoutis, et al.Inflammatory Process in Type 2 Diabetes The Role of Cytokines[J].Annals New York academy of sciences ,2006,1084(11):89-117.
[5]
Akash M S, Rehman K, Chen S. Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus[J]. J Cell Biochem,2013,114(3):525-531.
2015, Vol. 26 
