Abstract： Objective To investigate the correlations between serum BNP levels and the incidence of adverse cardiovascular events in patients with diabetes complicated with acute coronary syndrome.Methods Clinical data on 221 patients with acute coronary syndromes complicated with diabetes mellitus treated in our hospital was retrospectively analyzed, All these patients had their levels of BNP detected and received cardiac ultrasound and coronary angiography. The cardiac function of the patients was evaluated before they were divided into the ascending group (>100 pg/ml) and normal group (<100 pg/ml) according to BNP levels. The correlations between elevated BNP levels and cardiac function grading, ejection fraction and coronary artery lesion severity were investigated. Follow-up was conducted two months, six months and 12 months after the onset, involving such indexes as mortality and cardiovascular events before the difference in outcome indicators were compared between the two groups.Results (1) Among the 144 cases of patients with elevated BNP, there were 48 cases of cardiac function grade Ⅱ, the BNP concentration was (223.0±89.1)pg/ml, LVEF was (60.3±8.3)%, and the Gensin score of coronary artery lesions was(27.4±10.8) points. Among the 52 cases of cardiac function grade Ⅲ, the BNP concentration was(423±125.5 )pg/ml, LVEF was (46.5±7.4)%, and the Gensin score of coronary artery lesions was (56.5±18.4). Among the 44 cases of cardiac function grade Ⅳ, the BNP concentration was (665.0±157.5) pg/ml, LVEF was (35.0~4.5)%, and the Gensin score of coronary artery lesions was(83.1±29.7)points. The difference in LVEF and BNP levels and in coronary artery lesion severity was statistically significant between patients of different grades of cardiac function. The BNP level was negatively correlated with LVEF, which was positively correlated with the severity of coronary artery disease and cardiac function. (2) There was no statistically significant difference in the death toll or the number of patients with recurring myocardial infarction 2, 6 months and 12 months after the onset, but there was statistically significant difference in the number of inpatients due to recurring myocardial infarction. Kaplan-meier analysis showed that the survival rate of the ascending group was significantly higher than that in the normal group(P=0.019).Conclusions Serum BNP levels can be used as an indicator for the diagnosis and prediction of long-term adverse cardiovascular events in diabetic patients with acute coronary syndrome.
2018, Vol. 29 
