Abstract:Objective To find out about the epidemiological characteristics of respiratory viruses in hospitalized children with acute respiratory infections in Pingxiang Maternal and Child Health Hospital.Methods The clinical data of 7656 children with acute respiratory tract infection hospitalized between July 2018 and June 2019 in Pingxiang Maternal and Child Health Hospital was analyzed retrospectively. The antigens of seven common respiratory viruses in nasopharyngeal secretions of children were detected by direct immunofluorescence assay. These seven common respiratory pathogens included respiratory syncytial virus, influenza virus A, influenza virus B, parainfluenza virus Ⅰ, Ⅱ, Ⅲ and adenovirus. Statistical analysis of data was conducted using SPSS19.0 software.Results In the 7,656 cases, the positive rate of at least one virus was 25.57%. The top three viruses were respiratory syncytial virus (13.39%), adenovirus (4.79%) and influenza A virus (3.24%). The rate of virus detection was 30.11% in the group under1 year old, 25.79% in the group aged 1 to less than 3, 21.80% in the group aged 3 to less than 6 and 16.08% in the group aged 6 or above.The younger the age, the higher the detection rate of virus. There was difference of statistical significance in the positive rate of virus between these age groups. The highest detection rate of respiratory syncytial virus was 21.51% in children less than 1 year old and 10.27% in children less than 6 years old. There was no significant difference in the positive rate of the seven viruses between different genders. The incidence of RSV and IFVA infections was the highest in winter and spring, compared with April and June for ADV andIFVB.Other viruses were distributed throughout the year. Twelve of these cases (0.16%) were co-infected with two kinds of viruses.Conclusions Virus is the main pathogen of acute respiratory tract infections in children. The identification of the epidemiology of respiratory tract infection viruses in this area can guide clinical diagnosis and treatment.
Huang G, Yu D, Mao N, et al. Viral etiology of acute respiratory infection in Gansu Province [J]. PLoS One,2013,8:e64254.
[2]
Wang H, Zheng Y, Deng J, et al. Prevalence of respiratory viruses among children hospitalized from respiratory infections in Shenzhen [J]. Virol J,2016,13:39.
[3]
Mohammad Reza Etemadi, Farid Azizi Jalilian, Norlijah Othman, e.Diversity of respiratory viruses detected among hospitalized children with acute lower respiratory tract infections at Hospital Serdang[J].J Virol Methods,2019,269:1-6.
[4]
Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals [J].Lancet,2016,388:3027-3035.
[5]
Khor C S, Sam I C, Hooi P S, et al. Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years[J]. BMC Pediatr,2012,12:32.
[6]
Zimmerman R K, Rinaldo C R, Nowalk M P, et al. Influenza and other respiratory virus infections in outpatients with medically attended acute respiratory infection during the 2011-12 influenza season[J]. Influenza Other Respir Viruses,2014,8:397-405.
[7]
Pierangeli A, Gentile M, Di Marco P, et al.Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome[J]. J Med Virol,2007,79:463-468.
Zimmerman R K, Rinaldo C R, Nowalk M P, et al. Influenza and other respiratory virus infections in outpatients with medically attended acute respiratory infection during the 2011-12 influenza season[J]. Influenza Other Respir Viruses,2014,8:397-405.
[10]
Martins Júnior R B, Carney S, Goldemberg D, et al. Detection of respiratory viruses by real-time polymerase chain reaction in outpatients with acute respiratory infection[J]. Mem Inst Oswaldo Cruz,2014,109:716-721.
Oumei H, Xuefeng W, Jianping L,et al. Etiology of community-acquired pneumonia in 1500 hospitalized children[J]. J Med Virol,2018,90: 421-428.
[13]
Brini I, Guerrero A, Hannachi N, et al. Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area[J]. PLoS One,2017,12: e0188325.