Abstract：Objective To investigate the therapeutic effect of oligomeric proanthocyanidins (OPC) against ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in mice and explore the protective mechanism of OPC.Methods 32 male C57 mice were fed with 2.5% DSS to establish a UC model, which were randomly divided into the model group, treatment control group (mesalazine, 500 mg/kg), low dose group (OPC, 500 mg/kg) and high dose group (OPC, 1000 mg/kg), with 8 mice in each group. At the same time, another 8 male C57 mice were used as the control group and fed with normal water. After 7 days, the mice were sacrificed to evaluate the disease activity index (DAI), observe the pathological changes and evaluate the CMDI, detect the level of serum IL-10 and assay the activity of myeloperoxidase (MPO) in the colon.Results Compared with the normal control group, the DAI score increased significantly, the length of the colon decreased, the colonic mucosa became thinner,the epithelium was exfoliated and inflammatory cells were infiltrated in UC model groups. The level of serum IL-10 decreased significantly, and the activity of MPO improved significantly (P<0.05). Compared with the model control group, the indexes of each group significantly improved (P<0.05), but there was no significant difference between the high dose group and the treatment control group.Conclusions In mice with UC induced by DSS, OPC may help ameliorate DAI and improve the pathological morphology of colon tissue of mice by reducing oxidative stress and inhibiting inflammatory reactions.
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LV Xiaonan, DONG Zheng, LI Chunjin, CAO Yipo, LI Ying, MA Bo, YAO Min. Protective effect of oligomeric proanthocyanidins on dextran sulfate sodium induced ulcerative colitis in mice. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(7): 572-575.
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2020, Vol. 31 
