Effects of vitamin D supplementation on depressive symptoms in elderly patients with chronic musculoskeletal pain
LIU Chi1, HE Jing2, JIN Ying2, ZHANG Yaonan1
1. Department of Orthopedics, 2. Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing l00730, China
Abstract：Objective To investigate the effect of vitamin D supplementation on depressive symptoms in elderly patients with chronic musculoskeletal pain. Methods A total of 152 patients with chronic musculoskeletal pain and depression who were hospitalized between October 2019 and October 2020 in the Department of Orthopedics and Neurology of Beijing Hospital were selected, who were aged 60 to 80. The patients were divided into the intervention group (n=76) and the observation group (n=76) using the random number table method. In addition to conventional treatment, the two groups were supplemented with vitamin D. Both groups received vitamin D3 supplementation of 2000U (intervention group) or 400U (control group) daily for 12 weeks, respectively. The main outcome measures included the Geriatric Depression Scale (GDS-30) questionnaire and 25-hydroxyvitamin D [25(OH)D]. The chi-square test was used for the comparison of classified variables while the Mann Whitney U test and Wilcoxon signed rank sum test were used for the comparison of continuous variables. Multiple regression analysis was conducted with the depression score as the dependent variable to evaluate the influencing factors of depressive symptoms. Results A total of 148 subjects were enrolled, including 75 in the intervention group and 73 in the control group. There was no statistically significant difference in the shedding rate and elimination rate between the two groups. There was no significant difference in gender, age, levels of education, lifestyles or concomitant diseases between the two groups. The median baseline concentration of 25(OH)D was 12.4 ng/ml in the intervention group and 12.8 ng/ml in the control group. The depression scores of the two groups before intervention were 15 and 14 respectively (Z=1.714). After 12 weeks, 25(OH)D increased to 34.6 ng/ml in the intervention group (P<0.05) and to 19.5 ng/ml in the control group.Depression scores decreased from 15 points to 12 points in the intervention group (P<0.05), and from 14 points to 13 points in the control group.The increase of 25(OH)D levels and the improvement of depression in the intervention group were significantly better than in the control group. Multiple regression analysis showed that intervention grouping and pre-intervention depression scores were influencing factors of post-intervention depression scores (R2=0.727,F=62.459,P<0.05). Conclusions Vitamin D supplementation may reduce depression scores in people aged 60 or above and contribute to the improvement of depressive symptoms in elderly patients with chronic musculoskeletal pain.
刘驰, 何婧, 金莹, 张耀南. 维生素D对老年慢性肌肉骨骼疼痛患者抑郁症状的影响[J]. 武警医学, 2021, 32(10): 876-879.
LIU Chi, HE Jing, JIN Ying, ZHANG Yaonan. Effects of vitamin D supplementation on depressive symptoms in elderly patients with chronic musculoskeletal pain. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(10): 876-879.
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2021, Vol. 32 
