Abstract：Objective To investigate the artificial assisted reproductive technology (assisted reproductive technology,ART)and the clinical outcome of premature twins born naturally.Methods A total of 364 premature twins (182 pairs) hospitalized in pediatrics from January 2015 to December 2020 were collected, and divided into ART group (78 pairs) and natural pregnancy group (104 pairs) according to different pregnancy methods. The neonatal complications of twin preterm birth in the two groups were analyzed retrospectively. The general conditions of mother pregnancy, complications, gestational weeks of twin preterm birth, Apgar score, twin weight and weight difference, postnatal respiratory distress syndrome, neonatal intrauterine infectious pneumonia, neonatal hypoglycemia, nosocomial infection, application of respiratory support, application of Central venous catheterization (PICC and/or UVC), grade Ⅲ~Ⅳ intracranial hemorrhage,patent ductus arteriosus(≥3.0 mm), bronchopulmonary dysplasia(BPD), retinopathy of prematurity (ROP), length of hospital stay and time of intravenous nutrition were compared between the two groups.Results The maternal age of more than 35 years in the ART group (19.7%) was higher than that in the natural pregnancy group (14.2%). Gestational diabetes, hypertension and hypothyroidism in the ART group were higher than those in the natural pregnancy group, and the difference was statistically significant(P<0.05). The incidence of severe asphyxia and neonatal intrauterine infectious pneumonia in the ART group were higher than those in natural pregnancy group(χ2=5.317), and the incidence of BPD and central venous catheterization (including PICC and/or UVC, χ2=8.144) and the time of intravenous nutrition (t=2.073, P<0.05) were higher than those in natural pregnancy group (P<0.05) .Conclusions Premature twin infants with ART are prone to severe asphyxia, neonatal respiratory distress syndrome and intrauterine infectious pneumonia. Perinatal care and management of premature twin infants should be strengthened to avoid adverse outcomes.
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2022, Vol. 33 
