脑脊液肿瘤细胞学检查在视网膜母细胞瘤诊疗中的价值

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (3223 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the application value of cerebrospinal fluid (CSF) cytology examination in diagnosis and treatment of retinoblastoma. Methods We reviewed the results of CSF cytology examination by cytomorphology (CM) and flow cytometry (FC) for detecting early metastasis of retinoblastoma (RB) during July 2011 to July 2014. 125 cases of CSF cytology examination and prognosis were retrospectively analyzed. Results 125 CSF samples from 125 newly diagnosed RB patients were detected by CM before treatment,24 patients had a positive first sample by initial cytology examination. Patients with positive CSF samples by cytology examination tended to a poorer prognosis than patients with negative first sample. At the time of diagnosis, patients with imaging change of nervous system metastasis tended to a poor survival than patients with positive cytology only at initial samples, mean survival time (3.3 months vs 8.6 months, P=0.021); mortality rate (100% vs 81%, P=0.19). FC retained significantly more sensitivity than that of CM (sensitivity 90% vs 58%,P＜0.01).Conclusions Diagnosis of RB involving CSF with application of CM and FC can improve the detection rate.Havenmore intensive chemotherapy (including system and intrathecal chemotherapy) immediately after diagnosis might be beneficial for timely treating and it also prolonged these patients’ survival.

Key words： retinoblastoma cerebrospinal fluid cytology examination diagnosis and treatment

Received: 15 February 2015

ZTFLH:

R725.5

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XIE Nanli
	SUN Yanfeng
	WANG Jun
	LIU Hongyan
	MIAO Lixia
	YUAN Hailian
	LI Yanshan
	ZHANG Xianglan
	YANG Xinji
	LIU Qiuling

Cite this article:

XIE Nanli,SUN Yanfeng,WANG Jun等. Value of cerebrospinal fluid cytology examination in diagnosis and treatment of children retinoblastoma[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(8): 791-796.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I8/791

[1]	Dimaras H, Kimani K, Dimba E A, et al. Retinoblastoma [J]. Lancet, 2012, 379(9824):1436-1446.
[1]	Dimaras H, Kimani K, Dimba E A, et al. Retinoblastoma [J]. Lancet, 2012, 379(9824):1436-1446.
[2]	Finger P T, Harbour J W, Karcioglu Z A, et al.Risk factors for metastasis in retinoblastoma[J].Surv Ophthalmol,2002,47(1):1-16.
[2]	Finger P T, Harbour J W, Karcioglu Z A, et al.Risk factors for metastasis in retinoblastoma[J].Surv Ophthalmol,2002,47(1):1-16.
[3]	Linn Murphree A. Intraocular retinoblastoma: the case for a new group classification[J]. Ophthalmol Clin North Am, 2005, 18(1): 41-53.
[3]	Linn Murphree A. Intraocular retinoblastoma: the case for a new group classification[J]. Ophthalmol Clin North Am, 2005, 18(1): 41-53.
[4]	Reese A B, Ellsworth R M. The evaluation and current concept of retinoblastoma therapy[J]. Trans Am Acad Ophthalmol Otolaryngol,1963, 67: 64-172.
[5]	Bakhshi S, Meel R, Kashyap S, et al.Bone marrow aspirations and lumbar punctures in retinoblastoma at diagnosis: correlation with IRSS staging[J]. J Pediatr Hematol Oncol, 2011, 33(5):182-185.
[4]	Reese A B, Ellsworth R M. The evaluation and current concept of retinoblastoma therapy[J]. Trans Am Acad Ophthalmol Otolaryngol,1963, 67: 64-172.
[6]	王一卓,黄东生,史季桐,等. CSF中找肿瘤细胞在视网膜母细胞瘤中的应用价值[J]. 实用儿科临床杂志,2010,28(3):188-189.
[5]	Bakhshi S, Meel R, Kashyap S, et al.Bone marrow aspirations and lumbar punctures in retinoblastoma at diagnosis: correlation with IRSS staging[J]. J Pediatr Hematol Oncol, 2011, 33(5):182-185.
[7]	Azar D, Donaldson C, Dalla-Pozza L. Questioning the need for routine bone marrow aspiration and lumbar puncture in patients with retinoblastoma[J]. Clin Experiment Ophthalmol,2003,31(1):57–60.
[6]	王一卓,黄东生,史季桐,等. CSF中找肿瘤细胞在视网膜母细胞瘤中的应用价值[J]. 实用儿科临床杂志,2010,28(3):188-189.
[8]	王一卓,黄东生,史季桐,等. 骨髓细胞学检查在视网膜母细胞瘤中的应用价值[J]. 临床儿科杂志,2011,33(3):273-275.
[7]	Azar D, Donaldson C, Dalla-Pozza L. Questioning the need for routine bone marrow aspiration and lumbar puncture in patients with retinoblastoma[J]. Clin Experiment Ophthalmol,2003,31(1):57–60.
[9]	Ozdemir H, Tacyildiz N, Unal E, et al.Clinical and epidemiological characteristics of retinoblastoma: correlation with prognosis in a Turkish pediatric oncology center[J]. Pediatr Hematol Oncol, 2007, 24(3):221-31.
[8]	王一卓,黄东生,史季桐,等. 骨髓细胞学检查在视网膜母细胞瘤中的应用价值[J]. 临床儿科杂志,2011,33(3):273-275.
[10]	Gündüz K, Kse K, Kurt RA, et al.Retinoblastoma in Turkey: results from a tertiary care center in Ankara[J].J Pediatr Ophthalmol Strabismus. 2013, 50(5):296-303.
[9]	Ozdemir H, Tacyildiz N, Unal E, et al.Clinical and epidemiological characteristics of retinoblastoma: correlation with prognosis in a Turkish pediatric oncology center[J]. Pediatr Hematol Oncol, 2007, 24(3):221-31.
[10]	Gündüz K, Kse K, Kurt RA, et al.Retinoblastoma in Turkey: results from a tertiary care center in Ankara[J].J Pediatr Ophthalmol Strabismus. 2013, 50(5):296-303.
[11]	顾龙君. 儿童急性淋巴细胞白血病诊疗建议(第三次修订草案)[J]. 中华儿科杂志,2006,24(5):392-395.
[11]	顾龙君. 儿童急性淋巴细胞白血病诊疗建议(第三次修订草案)[J]. 中华儿科杂志,2006,24(5):392-395.
[12]	Wasserstrom W R, Glass J P, Posner J B. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients [J]. Cancer. 1982, 49(4):759-772.
[13]	Gomes H R.Cerebrospinal fluidapproach on neuro-oncology[J]. Arq Neuropsiquiatr, 2013, 71(9B):677-80.
[12]	Wasserstrom W R, Glass J P, Posner J B. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients [J]. Cancer. 1982, 49(4):759-772.
[13]	Gomes H R.Cerebrospinal fluidapproach on neuro-oncology[J]. Arq Neuropsiquiatr, 2013, 71(9B):677-80.
[14]	Bryson G J, Lear D, Williamson R, et al. Detection of the CD56+/CD45 immunophenotype by flow cytometry in neuroendocrine malignancies[J].J Clin Pathol,2002, 55(7):535-537.
[14]	Bryson G J, Lear D, Williamson R, et al. Detection of the CD56+/CD45 immunophenotype by flow cytometry in neuroendocrine malignancies[J].J Clin Pathol,2002, 55(7):535-537.
[15]	Shen H, Tang Y, Xu X, et al. Rapid detection of neoplastic cells in serous cavity effusions in children with flow cytometry immunophenotyping [J]. Leuk Lymphoma, 2012, 53(8):1509-1514.
[15]	Shen H, Tang Y, Xu X, et al. Rapid detection of neoplastic cells in serous cavity effusions in children with flow cytometry immunophenotyping [J]. Leuk Lymphoma, 2012, 53(8):1509-1514.

[1]	. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(2): 150-151.