两种化疗方案对转移性乳腺癌外周血T细胞亚群 和临床预后影响的比较

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Abstract Objective To investigate the effect of bevacizumab combined with TH chemotherapy on T cell subsets in peripheral blood and clinical prognosis in human epidermal growth factor receptor 2 (Her-2) positive patients with metastatic breast cancer.Methods Between Jan, 2012 and Jan, 2014, 100 patients with Her-2 positive metastatic breast cancer were prospectively recruited in this study. These patients were randomly assigned into a study group or a control group. The study group was treated with bevacizumab combined with TH chemotherapy while the control group was treated with TH chemotherapy alone. The patients were followed up for two years.The primary outcomes included CD4⁺T cells, CD8⁺T cells, solid tumor efficacy evaluation grades, progression free survival and 2-year mortality.Results There was no significant difference in CD8⁺T cells between the two groups before and after treatment. After treatment, the expression of CD4⁺T cells in the study group (P=0.422) was significantly higher than that in the control group (P=0.011). The rates of complete remission, partial remission, stable disease and progressive disease in the study groups were 0.00%, 36.00%, 42.00% and 22.00%, compared to 0.00%, 18.00%, 44.00% and 38.00% in the control group (P=0.025). Two years later, 9 patients in the study group died, and the mortality rate was 18.00%, while 20 patients in the control group died, and the mortality rate was 40.00%. The difference was statistically significant (P=0.015). Wilcoxon test showed that the duration of progression free survival in the study group was significantly longer than that in the control group (P=0.007).Conclusions The combination of bevacizumab and TH chemotherapy in patients with Her-2-positive metastatic breast cancer may help to improve the immune function and clinical prognosis.

Key words： metastatic breast cancer human epidermal growth factor receptor-2 T cell subsets progression free survival quality of life

Received: 08 December 2016

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	Articles by authors
	LV You
	WANG Xiaoyue
	SHI Chaofan
	and JIANG Wei

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LV You,WANG Xiaoyue,SHI Chaofan等. Effect of combination of bevacizumab and TH regimen chemotherapy on T cell subsets in peripheral blood and clinical prognosis of Her-2 positively metastatic breast cancer[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(6): 605-608.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I6/605

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