格列苯脲与胰岛素治疗妊娠糖尿病安全性的Meta分析

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Abstract Objective To systematically evaluate the safety of glyburide and insulin in the treatment of gestational diabetes mellitus in order to provide reference for clinical treatment.Methods Related articles were retrieved from CNKI, CBM, WanFang Database, Embase, Cochrane and PubMed from inception to November of 2018. Randomized controlled trials were collected in strict accordance with the inclusion and exclusion criteria. Two reviewers independently screened the literature. Endnote X8 was adopted to select eligible literature and data was extracted for quality assessment. RevMan 5.3 software was used for meta-analysis and descriptive statistical analysis. Outcome indicators included in this study were calculated.Results A total of 2115 patients were enrolled in seven randomized controlled trials. A total of six outcome indicators were analyzed. Meta-analysis showed that compared with the insulin group, the proportion of neonatal hypoglycemia was significantly increased in the glyburide group (OR=1.93, 95% CI=1.10-3.39), but there was no statistically significant difference in macrosomia (OR=0.89, 95% CI=0.68-1.17), the number of newborns admitted to the neonatal intensive care unit(OR=0.71, 95% CI=0.44-1.14), premature delivery (OR=1.26, 95%CI=0.88-1.99), neonatal hyperbilirubinemia (OR=0.77, 95% CI=0.52-1.16) or the number of cases of cesarean section (OR=0.87, 95% CI=0.67-1.13).Conclusion Studies of pregnant women with gestational diabetes have shown that there is no significant difference in safety between glyburide and insulin therapies as long as neonatal hypoglycemia is detected without delay.

Key words： glyburide insulin gestational diabetes Meta-analysis systematic review

Received: 06 December 2018

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	Articles by authors
	LIU Jinlong
	ZHANG Yan
	HOU Haiyan
	WANG Chao
	CHANG Yu
	CHEN Xiao

Cite this article:

LIU Jinlong,ZHANG Yan,HOU Haiyan等. Safety of glyburide and insulin in the treatment of gestational diabetes mellitus: a meta-analysis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(5): 397-401.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I5/397

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