卵巢功能减退患者多周期累积与非累积胚胎移植临床结局比较

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Abstract Objective To investigate the clinical outcomes in vitro fertilization-embryo transfer (IVF-ET) in patients with diminished ovarian reserve (DOR) after multi-cycle cumulative and non-cumulative embryo transfer strategies. Methods Clinical data of 174 patients with DOR who underwent IVF-ET treatment in the Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University from January 2019 to December 2022 were retrospectively analyzed. All the included patients had completed all embryo transfer and final follow-up. Basic endocrine, anti-mullerian hormone levels and sinus follicle counts of the patients were collected, and relevant clinical data such as ovarian response parameters and pregnancy outcomes after ovulation induction therapy were recorded.The clinical outcomes of multi-cycle cumulative embryo transfer (cumulative group) and non-cumulative embryo transfer (non-cumulative group) were compared. Results No statistically significant differences were found in terms of cumulative pregnancy rate (35.24% vs. 27.54%), early abortion rate (32.43% vs. 26.32%), and cumulative live birth rate (21.90% vs. 18.84%) between the two groups of DOR patients with multiple-cycle cumulative embryo transfer and non-cumulative embryo transfer (P>0.05). logistic regression analysis was performed after taking into account multiple factors such as transplantation strategy, BMI, age of first egg retrieval, AMH, number of embryo transfer, number of high-quality embryo transfer, and cumulative number of eggs obtained, and two different embryo transfer strategies (OR=1.522, 95% CI 0.608-3.814) had no significant impact on live birth (P>0.05). Conclusions For patients with DOR, cumulative embryo transfer after multiple cycles of repeated egg retrieval can not improve the cumulative pregnancy rate and live birth rate.

Key words： diminished ovarian reserve cumulative embryo transfer cumulative live birth rate in multiple cycles

Received: 20 September 2023

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	WANG Yuwei
	WANG Cong
	FANG Ying
	YANG Xiaokui

Cite this article:

WANG Yuwei,WANG Cong,FANG Ying等. Comparison of clinical outcomes between multi-cycle accumulative embryo transfer and non-accumulative embryo transfer in patients with diminished ovarian reserve[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(4): 307-311.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2024/V35/I4/307

[1]	Pastore L M, Christianson M S, Stelling J, et al. Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR[J]. J Assist Reprod Genet, 2018,35(1):17-23.
[1]	Pastore L M, Christianson M S, Stelling J, et al. Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR[J]. J Assist Reprod Genet, 2018,35(1):17-23.
[2]	Zhang Y, Zhang C, Shu J, et al. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis[J]. Hum Reprod Update, 2020,26(2):247-263.
[2]	Zhang Y, Zhang C, Shu J, et al. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis[J]. Hum Reprod Update, 2020,26(2):247-263.
[3]	Yu R, Jin H, Huang X, et al. Comparison of modified agonist, mild-stimulation and antagonist protocols for in vitro fertilization in patients with diminished ovarian reserve[J]. J Int Med Res, 2018,46(6):2327-2337.
[3]	Yu R, Jin H, Huang X, et al. Comparison of modified agonist, mild-stimulation and antagonist protocols for in vitro fertilization in patients with diminished ovarian reserve[J]. J Int Med Res, 2018,46(6):2327-2337.
[4]	Hu S, Xu B, Jin L. Perinatal outcome in young patients with diminished ovarian reserve undergoing assisted reproductive technology[J]. Fertil Steril, 2020,114(1):118-124.
[4]	Hu S, Xu B, Jin L. Perinatal outcome in young patients with diminished ovarian reserve undergoing assisted reproductive technology[J]. Fertil Steril, 2020,114(1):118-124.
[5]	Ata B, Seyhan A, Seli E. Diminished ovarian reserve versus ovarian aging: overlaps and differences[J]. Curr Opin Obstet Gynecol, 2019, 31(3): 139-147.
[5]	Ata B, Seyhan A, Seli E. Diminished ovarian reserve versus ovarian aging: overlaps and differences[J]. Curr Opin Obstet Gynecol, 2019, 31(3): 139-147.
[6]	中国医师协会生殖医学专业委员会.基于单次促排卵周期的累积分娩/活产率专家共识[J]. 中华生殖与避孕杂志, 2018, 38(12): 963-968.
[6]	中国医师协会生殖医学专业委员会.基于单次促排卵周期的累积分娩/活产率专家共识[J]. 中华生殖与避孕杂志, 2018, 38(12): 963-968.
[7]	Takahashi T, Igarashi H, Amita M, et al. Molecular mechanism of poor embryo development in postovulatory aged oocytes: mini review[J]. J Obstet Gynaecol Res, 2013, 39(10): 1431-1439.
[7]	Takahashi T, Igarashi H, Amita M, et al. Molecular mechanism of poor embryo development in postovulatory aged oocytes: mini review[J]. J Obstet Gynaecol Res, 2013, 39(10): 1431-1439.
[8]	Han L, Wang H, Li L, et al. Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway[J]. J Pineal Res, 2017, 63(3):1-29.
[8]	Han L, Wang H, Li L, et al. Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway[J]. J Pineal Res, 2017, 63(3):1-29.
[9]	Chen Y H, Xu X H, Wang Q, et al. Optimum oocyte retrieved and transfer strategy in young women with normal ovarian reserve undergoing a long treatment protocol:a retrospective cohort study[J]. J Assist Reprod Genet, 2015, 32(10):1459-1467.
[9]	Chen Y H, Xu X H, Wang Q, et al. Optimum oocyte retrieved and transfer strategy in young women with normal ovarian reserve undergoing a long treatment protocol:a retrospective cohort study[J]. J Assist Reprod Genet, 2015, 32(10):1459-1467.
[10]	刘景, 周梦鸽, 李真, 等. 女性年龄与获卵数对体外受精-胚胎移植累积活产率的影响[J]. 郑州大学学报(医学版), 2022, 57(4): 547-551.
[10]	刘景, 周梦鸽, 李真, 等. 女性年龄与获卵数对体外受精-胚胎移植累积活产率的影响[J]. 郑州大学学报(医学版), 2022, 57(4): 547-551.
[11]	Vaiarelli A, Cimadomo D, Ubaldi N, et al. What is new in the management of poor ovarian response in IVF?[J]. Curr Opin Obstet Gynecol, 2018, 30(3): 155-162.
[11]	Vaiarelli A, Cimadomo D, Ubaldi N, et al. What is new in the management of poor ovarian response in IVF?[J]. Curr Opin Obstet Gynecol, 2018, 30(3): 155-162.
[12]	Law Y J, Zhang N, Venetis C A, et al. The number of oocytes associated with maximum cumulative live birth rates per aspiration depends on female age: a population study of 221 221 treatment cycles[J]. Hum Reprod, 2019, 34(9): 1778-1787.
[12]	Law Y J, Zhang N, Venetis C A, et al. The number of oocytes associated with maximum cumulative live birth rates per aspiration depends on female age: a population study of 221 221 treatment cycles[J]. Hum Reprod, 2019, 34(9): 1778-1787.
[13]	Goldman R H, Racowsky C, Farland L V, et al. Predicting the likelihood of live birth for elective oocyte cryopreservation: a counseling tool for physicians and patients[J]. Hum Reprod, 2017, 32(4): 853-859.
[13]	Goldman R H, Racowsky C, Farland L V, et al. Predicting the likelihood of live birth for elective oocyte cryopreservation: a counseling tool for physicians and patients[J]. Hum Reprod, 2017, 32(4): 853-859.
[14]	Gu F, Ruan S, Luo C, et al. Can repeat IVF/ICSI cycles compensate for the natural decline in fertility with age? an estimate of cumulative live birth rates over multiple IVF/ICSI cycles in Chinese advanced-aged population[J]. Aging (Albany NY), 2021,13(10):14385-14398.
[14]	Gu F, Ruan S, Luo C, et al. Can repeat IVF/ICSI cycles compensate for the natural decline in fertility with age? an estimate of cumulative live birth rates over multiple IVF/ICSI cycles in Chinese advanced-aged population[J]. Aging (Albany NY), 2021,13(10):14385-14398.
[15]	李欣, 周星宇, 张俊, 等. 高龄女性累积胚胎后移植与非累积胚胎移植的妊娠结局分析[J]. 广东医学, 2021, 42(8): 877-882.
[15]	李欣, 周星宇, 张俊, 等. 高龄女性累积胚胎后移植与非累积胚胎移植的妊娠结局分析[J]. 广东医学, 2021, 42(8): 877-882.
[16]	Yang J H, Chen C D, Chen S U, et al. Factors influencing the recurrence potential of benign endometrial polyps after hysteroscopic polypectomy[J]. PLoS One, 2015, 10(12): e144857.
[16]	Yang J H, Chen C D, Chen S U, et al. Factors influencing the recurrence potential of benign endometrial polyps after hysteroscopic polypectomy[J]. PLoS One, 2015, 10(12): e144857.
[17]	Mossa B, Patella A, Ebano V, et al. Microsurgery versus laparoscopy in distal tubal obstruction hysterosalpingographically or laparoscopically investigated[J]. Clin Exp Obstet Gynecol, 2005, 32(3): 169-171.
[17]	Mossa B, Patella A, Ebano V, et al. Microsurgery versus laparoscopy in distal tubal obstruction hysterosalpingographically or laparoscopically investigated[J]. Clin Exp Obstet Gynecol, 2005, 32(3): 169-171.