Effect of dexmedetomidine and general anesthesia combined with inhalation in laparoscopic treatment of adults with indirect inguinal hernia in plateau
DENG Feng1, KANG Jian1, LIANG Qingshan2
1. Department of Anesthesiology, 2. the First Department of Surgery, Tibet Autonomous Regional Corps Hospital of Chinese People’s Armed Police Force, Lhasa 850000, China
Abstract：Objective To study the clinical effect of dexmedetomidine and general anesthesia combined with inhalation in laparoscopic treatment of adults with indirect inguinal hernia in plateau. Methods A total of 97 patients who were treated with laparoscopic treatment of indirect inguinal hernia in Tibet Autonomous Regional Corps Hospital of Chinese People’s Armed Police Force from December 2020 to December 2022 were selected as subjects, and divided into observation group (n=48) and control group (n=49) by random number table method. The control group were given general anesthesia combined with inhalation, while the observation group were given dexmedetomidine and general anesthesia combined with inhalation. The general condition, anesthesia quality, hemodynamics, stress response, inflammatory factors and incidence of complications were compared between the two groups. Results The onset time of anesthesia [(6.37±1.24)min] and extubation time [(13.88±4.30) min] in the observation group were smaller than those in the control group [ (9.12±3.45) min and (21.27±7.30)min; P<0.05]. The blood pressure during intoxication time in the observation group [(126.30±12.45)/(76.38±6.80)mmHg] was higher than that in the control group [(120.15±10.37)/(71.44±4.93)mmHg]. The heart rate[(73.41±10.07) times/min], mean arterial pressure [(86.39±14.07)mmHg] and heart index (2.38±0.77) in the observation group were lower than those in the control group [(79.60±11.53)times/min,(98.13±17.22)mmHg and(2.76±0.93). There was no significant difference in stress indexes and inflammatory factors between the two groups during anesthesia induction period(P>0.05). During anesthesia recovery period, the stress index cortisol, Ang Ⅱ and ALDO, inflammatory factor IL-6, CRP and TNF-α, and complication rate in the observation group were lower than those in the control group(P<0.05). Conclusions Dexmedetomidine and general anesthesia combined with inhalation can stabilize hemodynamics, reduce the levels of stress response and inflammatory factors, reduce the incidence of anesthesia complications and improve the safety of anesthesia in adult patients with indirect inguinal hernia in plateaus.
邓峰, 康健, 梁青山. 右美托咪定联合静吸复合全身麻醉用于高原地区腹腔镜治疗成人腹股沟斜疝的效果[J]. 武警医学, 2025, 36(1): 34-38.
DENG Feng, KANG Jian, LIANG Qingshan. Effect of dexmedetomidine and general anesthesia combined with inhalation in laparoscopic treatment of adults with indirect inguinal hernia in plateau. Med. J. Chin. Peop. Armed Poli. Forc., 2025, 36(1): 34-38.
Shakil A, Aparicio K, Barta E, et al. Inguinal hernias: diagnosis and management[J]. Am Fam Physician, 2020,102(8):487-492.
[2]
Ortenzi M, Montori G, Sartori A, et al. Low-pressure versus standard-pressure pneumo- peritoneum in laparoscopic cholecystectomy: a systematic review and meta-analysis of randomized controlled trials[J]. Surg Endosc, 2022,36(10):7092-7113.
Vasunilashorn S M,Ngo L H,Inouye S K,et al.Apolipoprotein E genotype and the association between C-reactiveproteinandpostoperativedelirium:importanceofgene-proteininteractions[J].Alzheimers Dement,2021,16(3):572-580.
[6]
Wang Y, Cao M, Cao G, et al. Effect of combined intravenous-inhalation anesthesia on postoperative cognitive dysfunction after laparoscopic radical resection of cervical cancer: a protocol for systematic review and meta-analysis[J]. Medicine(Baltimore), 2020,99(45):e23124.
Mondardini M C, Sperotto F, Daverio M, et al. Efficacy and safety of dexmedetomidine for prevention of withdrawal syndrome in the pediatric intensive care unit: protocol for an adaptive, multicenter, randomized, double-blind, placebo-controlled, non-profit clinical trial[J]. Trials, 2019,20(1):710.
Wang X, Liu N, Chen J, et al. Effect of intravenous dexmedetomidine during general anesthesia on acute postoperative pain in adults: a systematic review and meta-analysis of randomized controlled trials[J]. Clin J Pain, 2018,34(12):1180-1191.
2025, Vol. 36 
