Abstract：Objective To analyze risk factors for chronic obstructive pulmonary disease (COPD) complicated with lung cancer and propose corresponding preventive strategies. Methods A retrospective study was conducted on 55 COPD patients complicated with lung cancer (COPD with lung cancer group) and 110 patients with COPD alone ( COPD alone group) admitted to the General Hospital of PLA Southern Theater Command from March 2022 to March 2024. Clinical data and laboratory indicators were collected. Univariate and multivariate logistic regression analyses were performed to identify risk factors, and Receiver Operating Characteristic (ROC) curves were constructed to evaluate predictive performance. Results Univariate logistic regression analysis showed that the COPD with lung cancer group had higher proportions of age ≥65 years, male patients and farmers, longer COPD duration, higher smoking index, elevated Interleukin-17 (IL-17) levels, and increased platelet count than the COPD al one group (P＜0.05) . Multivariate logistic regression analysis identified occupation ( OR=2.23 1,9 5%CI=1. 074~4. 636 ), smoking index ( OR=2. 381 ,95 % CI=1.125~5. 039 ) , COPD duration ( OR=1.209, 95% CI=1. 092~1.338 ), IL-17 ( OR=1.374 ,95%CI=1. 008~1. 873 ) , and platelet count ( OR = 1. 072,9 5 % CI = 1. 043 ~ 1. 101 ) as independent risk factors for COPD patients complicated with lung cancer. ROC analysis demonstrated that occupation, smoking index, COPD duration, IL-17 and platelet count all showed certain predictive efficacy for lung cancer in COPD patients. Conclusions Occupation as a farmer, smoking index=800, longer COPD duration, IL-17 levels, and increased platelet count are independent risk factors for COPD patients complicated with lung cancer, demonstrating good predictive efficacy.
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2025, Vol. 36 
