Abstract： Objective To evaluate the effect of norepinephrine on hemodynamic, renal function and myocardial enzymes in patients undergoing orthotopic liver transplantation. Methods Forty adult patients undergoing orthotopic liver transplantation were randomly divided into two groups: norepinephrine group (group N) and dopamine group (group D) (n=20). Hemodynamic variables, renal function and myocardial enzymes were measured respectively just before incision (T1), at 1 h after incision (T2), 30 min after the clamping of the portal vein (T3), 1 h (T4) and 4 h (T5) after the unclamping of the portal vein. Results Mean arterial pressure (MAP) was maintained to the target in both groups during the operation. Group N showed high MAP and low heart rate(HR) at T3 , compared with group D（P＜0.05）. β2-MG in group N was significantly lower than that in group D at T2 (P<0.05). Compared with T1, only CK increased significantly at T3（P＜0.05）, so did all the enzymes at T4-5（P＜0.05）. Conclusions Norepinephrine can maintain hemodynamic stability with low HR in patients undergoing orthotopic liver transplantation, without any deleterious effects on renal function and myocardial enzymes.
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Anderson W P, Korner P I, Selig S E. Mechanisms involved in the renal responses to intravenous and renal artery infusions of noradrenaline in conscious dogs［J］. J Physiol,1981,321:21-30.
Anderson W P, Korner P I, Selig S E. Mechanisms involved in the renal responses to intravenous and renal artery infusions of noradrenaline in conscious dogs［J］. J Physiol,1981,321:21-30.
2012, Vol. 23 
