Prevalence and risk factors of vertebral fracture after liver transplantation patients
WANG Hongyu1,XU Chun1,LIU Xiaojun2,NIU Yujian3
1.Endocrinology Department, The General Hospital of Chinese People’s Armed Police Forces,Beijing 100039,China; 2.Pharmacy Department, The General Hospital of Chinese People’s Armed Police Forces,Beijing 100039,China; 3.Organ Transplantation Institute,The General Hospital of Chinese People’s Armed Police Forces,Beijing 100039,China
Abstract：Objective To investigate the prevalence rate of vertebral fracture in a single transplant centre and analyze the disease risk factors. Methods Liver transplantation patients were enrolled from August 2011 to February 2013 in The General Hospital of Chinese People’s Armed Police Forces. Inclusion criteria:1.Liver transplantation for the first time; 2.Age of 20-70 years.Exclusion criteria:1.Pregnancy or lactation. 2.Other organ transplantation.The data collected from electronic medical records were as follows: demographic characteristics (age, gender, BMI), history of liver disease, immunosuppressive treatment. Frontal and lateral X-ray films of thoracolumbar spine was measured. Results 179 patients were analyzed, including 151 men and 28 women, aging from 30 to 69 years old (mean age 51.5 years).The prevalence rates of vertebral fracture was 32.4%.Prevalence of slight, medium and severe vertebral fractures were 74.1%,19.0% and 6.9%, respectively.0.5-2 years postoperatively with vertebral fracture prevalence was highest, 51.4%.Prevalence of vertebral fractures after the surgery mainly involved with glucocorticoid and calcineurin inhibitor dosage, in addition to age.After surgery, the use of diphosphonate could reduce the prevalence of vertebral fractures in patients with liver transplantation in Europe and the United States. Conclusions There are high vertebral fracture rates in patients undergoing liver transplantation. This rate is likely to reflect long-term use of glucocorticoid and immunosuppressants .It is suggested that we should, on the basis of calcium and vitamin D, select the double phosphonic acid salt to prevent and treat osteoporosis and bone fracture after liver transplantation.
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2014, Vol. 25 
