Abstract:Objective To analyze the clinical effect of kidney transplantation using the donation after cardiac death(DCD)donors in this center, explore the feasibility of DCD and summarize the experience of DCD donor kidney transplantation. Methods From April 2012 to December 2013, the clinical data of 28 cases of DCD and 52 cases of DCD donor renal transplantation were retrospectively analyzed in this center. Results 28 DCD cases were performed by the classification of Maastricht Ⅲ criteria, resulting in fifty-two donated kidney for transplantations. Warm ischemic time of donor was (11.2±9.1)minutes, cold ischemic time of donor (4.1±2.2)h. Among 52 cases of kidney transplant recipients,postoperative renal delayed graft function (DGF) occurred in 12 cases (23.08%, 12/52), their renal function returned to the normal level from postoperative day 20 to 72. 2 cases were subjected to nephrectomy due to the rupture of the transplanted kidney caused by the irreversible acute rejection (3.85%, 2/52) in one week and two weeks after kidney transplantation. There was one death due to cytomegalovirus pneumonia after three months postoperatively, one death due to primary non-function of renal graft and fungal pneumonia, one death due to rupture of kidney and septic shock. 47 renal transplant recipients with graft survival were followed up for 13 to 23 months,and the grafts functioned properly. Conclusions Donor pool can be largely expanded with DCD donors,the occurrence of complications should be paid attention to and the effects of DCD transplantation should be improved.
刘煜, 朱雄伟, 王毅, 刘航, 沈中阳. 心脏死亡器官捐献者供肾移植的可行性[J]. 武警医学, 2015, 26(7): 677-679.
LIU Yu, ZHU Xiongwei, WANG Yi, LIU Hang, SHEN Zhongyang. A single-center experience of 52 cases of donation after cardiac death (DCD) for kidney transplantation. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(7): 677-679.
Moers C,Leuvenink H G,Ploeg R J.Donation after cardiac death:evaluation of revisiting an important donor source[J]. Nephrol Dial Transplant, 2010, 25(3): 666-673.
[3]
Ledinh H,Meurisse N,Delbouile M H,et al.Contribution of doners after cardiac death to the deceased donor pool 2002 to 2009 University of Liege experience[J]. Transplant Proc, 2010, 42(10):4369-4372.
Kootstra G,Daemen J H,Oomen A P. Categories of non-heart beating donors [J]. Transplant Proc, 1995, 27(5):2893-2894.
[3]
Ledinh H,Meurisse N,Delbouile M H,et al.Contribution of doners after cardiac death to the deceased donor pool 2002 to 2009 University of Liege experience[J]. Transplant Proc, 2010, 42(10):4369-4372.
[5]
Sladen R N, Shonkwiler R J. Donation after cardiocirculatory death:back to the future [J] Can J Anaesth, 2011, 58(7): 591-594.
Snoeijs M G,Winkens B,Heemskerk M B,et al. Kidney transplantation from donors after cardiac death:a 25-year experience[J]. Transplantation, 2010,90(10):1106-1112.
[5]
Sladen R N, Shonkwiler R J. Donation after cardiocirculatory death:back to the future [J] Can J Anaesth, 2011, 58(7): 591-594.
Snoeijs M G,Winkens B,Heemskerk M B,et al. Kidney transplantation from donors after cardiac death:a 25-year experience[J]. Transplantation, 2010,90(10):1106-1112.