High-resolution microendoscopy for diagnosis pathological typing of gastric cancer
LIU Minli1,2, QU Yawei2, TAN Tao2, SHU Juan2, ZHANG Ling2, and LIU Haifeng2
LIU Minli1,2, QU Yawei2, TAN Tao2, SHU Juan2, ZHANG Ling2, and LIU Haifeng2.1.The Graduate School of Xuzhou Medical University, Xuzhou 221004, China; 2. Department of Gastroenterology, General Hospital of Chinese People’s Armed Police Force, Beijing 100039, China
Abstract：Objective To evaluate the diagnostic value of high-resolution microendoscopy in pathological typing of gastric cancer. Methods 40 biopsy specimens suspected of gastric cancer sampled from patients undergoing gastroscopy examination in the General Hospital of Chinese People’s Armed Police Force and 10 cases of surgical resected gastric cancer specimens from the Department of General Surgery were enrolled in this study. 10 cases of surgical resection specimen of gastric cancer were used for HRME imaging to summarize the characteristics of the HRME images and make the HRME diagnostic criteria of gastric cancer and its pathological type. Based on the criteria, the endoscopic biopsy specimens suspected of gastric cancer were used for HRME imaging to make a prior diagnosis, and compared the results with pathological results to assess the diagnostic value of HRME for gastric cancer. Results 32 patients were diagnosed as cases of gastric cancer by HRME in whom 29 cases were confirmed by histopathology. By statistical analysis, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 96.7%, 70.0%, 90.0%, 90.6%, and 87.5%, respectively. In consistency analysis, k value was 0.71. Fifteen patients were diagnosed as cases of differentiated gastric cancer in whom 12 patients were confirmed by histopathology. 14 patients were diagnosed as cases of undifferentiated gastric cancer in whom 12 patients were confirmed by histopathology. On statistical analysis, the diagnostic value showed that the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 80.0%, 85.7%, 82.8%, 85.7%, and 80.0%, respectively. Conclusions According to the high-resolution microendoscopy images, gastric cancer can be divided into differentiated and undifferentiated type with high diagnostic value.
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2016, Vol. 27 
