Clinical observation of dexmedetomidine in prevention of nausea and vomiting after laparoscopic hysteromyomectomy
JIANG Ye1,2,WANG Qingxiu1, and HE Hong2
1.Tongji University Medical School, Shanghai 200092,China; 2. Department of Gynecology, Changning Maternal and Child Health Hospital, Shanghai 051000, China
Abstract：Objective To study the effect of subclinical doses of dexmedetomidine on the prevention of nausea and vomiting after laparoscopic myomectomy.Methods One hundred and twenty patients scheduled to undergo laparoscopic myomectomy between June 2016 and December 2017 were selected. These patients were randomly divided into three groups: the dexmedetomidine group, the ramosetron group , and the metoclopramide group. In the dexmedetomidine group, the background dose was 0.4 μg/kg, and infusion was completed slowly (3-5 min). The ramosetron group was given remerstom 0.3 mg 30 min before the end of the operation. The metoclopramide group was given metoclopramide 20 mg 30 min before the end of surgery. The incidence of nausea and vomiting was observed in these three groups of patients 0-1 h, ＞1-3 h, ＞3-6 h, ＞6-12 h after extubation.Results There was no statistically significant difference in the incidence of postoperative nausea and vomiting between the three groups 3 h after surgery, but the incidence of postoperative nausea and vomiting in the dexmedetomidine group and the ramosetron group was significantly lower than that in the metoclopramide group (P<0.05).Conclusions Intravenous injection of some dose of dexmedetomidine before induction and intraoperative maintenance of small-dose infusion or a dose of ramosetron or metoclopramide (wintin 3 hour) 30 min before the end of surgery can all effectively prevent nausea and vomiting induced by laparoscopic hysteromyoma resection three hours after surgery. Dexmedetomidine and ramosetron are more effective than metoclopramide.
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JIANG Ye,WANG Qingxiu, and HE Hong. Clinical observation of dexmedetomidine in prevention of nausea and vomiting after laparoscopic hysteromyomectomy. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(5): 473-475.
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2018, Vol. 29 
