Abstract：Objective To study the effects of Ginkgo biloba extract on pharmacokinetics of clopidogrel and its mechanism.Methods Fourteen healthy male volunteers took a single 100-mg oral dose of clopidogrel either alone or after pretreatment with 240 mg Ginkgo biloba extract daily for 14 days. On day 14, a single 100-mg oral dose of clopidogrel was administered. Plasma SR26334 concentrations of clopidogrel from zero to 24 h were measured by high-performance liquid chromatography.Results AUC(0-t)(3192.3±45.035), AUC(0-∞)(3343.017±43.829) and Cmax(340.988±11.257) of SR26334 in the combination group was significantly higher than that of the single-drug group (P<0.05).Conclusions Ginkgo biloba extractcan increase the bioavailability and absorption of clopidogrel. The mechanism may be related to Ginkgo biloba’s significant inhibition of P-glycoprotein.
汪冬吟,黄秋玲,陈丽凤,陈志民. 银杏叶提取物对氯吡格雷人体内药动学影响[J]. 武警医学, 2018, 29(12): 1133-1137.
WANG Dongyin, HUANG Qiuling, CHEN Lifeng, and CHEN Zhimin. Effect of Ginkgo biloba extract on pharmacokinetics of clopidogrel and its mechanism. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(12): 1133-1137.
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2018, Vol. 29 
