Correlations between fibroblast growth factor-23 and femoral artery intima- media thickness in peritoneal dialysis patients
ZHANG Zhimin1, GAO Feng2, SHI Changqian2, HE Xiao2
1.Department of Outpatients,First Mobile Corps Hospital of Chinese People’s Armed Police Force,Dingzhou 073000,China; 2.Department of Nephrology,Liaoning Provincial Corps Hospital of Chinese People’s Armed Police Force,Shenyang 110034,China
Abstract：Objective To observe the correlations between fibroblast growth factor-23(FGF-23) and femoral artery intima- media thickness(IMT) in peritoneal dialysis patients.Methods Patients on continuous ambulatory peritoneal dialysis(CAPD) were divided into different groups according the femoral artery IMT. The relationships between FGF-23 and femoral artery IMT in different CAPD groups were analyzed.Results The incidence of increased femoral artery IMT in CAPD patients was 45.12%. Age, and levels of serum phosphorous、HbA1c、intact parathyroid hormone( iPTH) and FGF-23 of the increased IMT group were significantly above those of the normal IMT group (P<0.05). According to multiple logistic regression analysis ,the levels of serum phosphorous、iPTH and a high FGF-23 concentration were significant independent risk factors for increased IMT in CAPD patients(P<0.05).Conclusions These results suggest that a high level of FGF-23 is an important indicator of calcium-phosphorus metabolism and vascular calcification in CKD patients, and maybe an important early warning signal of vascular calcification in CAPD patients.
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2019, Vol. 30 
