Abstract：Objective To analyze the correlations between peripheral blood C-reactive protein, lymphocytes and the pneumonia severity index in patients with influenza. Methods The 66 patients who were treated at our hospital between January 2019 and April 2019 were selected, whose clinical data such as sex, age, height, weight, smoking history, drinking history, onset time of fever, influenza type, blood routine test and pneumonia severity index was analyzed retrospectively. These cases were divided into the severe influenza group and mild influenza group based on the severity of disease. Single factor analysis was carried out on the demographic and clinical characteristics of the two groups to identify the influencing factors of severe pneumonia. Spearman correlation and linear regression were used to analyze the correlations between C-reactive protein, lymphocytes and the pneumonia severity index. Results The leukocyte count, platelet count, lymphocyte absolute value, lymphocyte percentage and monocyte absolute value in the severe influenza group were significantly lower than those in the mild influenza group, while the C-reactive protein level and pneumonia severity index were significantly higher (P< 0.05). The absolute value of lymphocytes was negatively correlated with the severity index and lymphocyte percentage of pneumonia (r=-0.6850, P<0.001), while C-reactive protein was positively correlated with the severity index of pneumonia (r=0.8523, P<0.001). Conclusions The decrease of lymphocytes, increase of C-reactive protein and pneumonia severity index are risk factors for severe influenza. C-reactive protein is positively correlated with the pneumonia severity index, which is negatively correlated with lymphocytes.
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2020, Vol. 31 
