Effects of ω-3 polyunsaturated fatty acids on inflammatory response in patients undergoing cardiac valve replacement
ZHANG Xuhui1, BAO Jie2, WANG Jinghua1, HU Wenjun1, LI Qian1, WANG Xinglei1, LIU Yan3
1. Department of Anesthesiology,No. 305 Hospital of PLA,Beijing 100017,China; 2. Department of Anesthesiology,Nanjing Drum Tower Hospital,Nanjing 210000,China; 3. Department of Anesthesiology,Beijing Municipal Corps Hospital of PAP,Beijing 100027,China
Abstract：Objective To evaluate the impact of ω-3 polyunsaturated fatty acids on levels of IL-6,TNF-α and IL-10 in patients undergoing cardiac valve replacement.Methods Sixty-two patients undergoing cardiac valve replacement in No.305 Hospital of PLA were randomly divided into two groups:the trial group (n=31) and control group (n=31).The patients in the trial group were administered with ω-3 polyunsaturated fatty acids 0.2 g/(kg·d) while the control group was administered with saline.The plasma concentrations of IL-6,TNF - α and IL-10 were measured before surgery,0.5 h after ascending aorta occlusion,2 h after cardiopulmonary bypass,and 12,24,48 h after surgery.Results After surgery (T0),the levels of TNF-α,IL-6 and IL-10 in the two groups were increased (P<0.05).The serum levels of TNF-α and IL-6 in the trail group were lower than those of the control group,but the level of IL-10 was higher,with statistically significant difference.Conclusions ω-3 polyunsaturated fatty acids can attenuate the inflammatory response in patients undergoing cardiac valve replacement to some extent.
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2020, Vol. 31 
