Abstract：Objective To analyze the characteristics of cardiopulmonary function in patients with ankylosing spondylitis (AS), and explore the influence of global kyphosis (GK) on cardiopulmonary function.Methods Retrospective analysis of the clinical data of 46 patients with AS complicated with kyphosis admitted to Beijing Dawang Lu Emergency Hospital from October 2021 to October 2022. According to the to global kyphosis Angle, they were divided into severe group (GK > 95°), 23 cases in the moderate group (80°≤ GK ≤ 95°). Statistical correlations of Pearson or Spearman were used to analyze the effect of GK angle on lung function indexes, and basic cardiac structure and functional parameters in both groups.Results As the GK angle increases, the diameter of the atrioventricular cavity (left atrial diameter, left ventricular diameter in end diastole, leftventriculardiameterinendsystole, right atrial diameter, right ventricular diameter), the ratio of early diastolic peak velocity to late diastolic peak velocity (E/A), and the ratio of early diastolic velocity to late diastolic velocity (e’/a’) of the mitral septal ring gradually decrease, while E/e’gradually increases, There was a significant statistical difference between groups (P<0.05).The pulmonary function results of the included patients showed: Compared with the moderate group, the severe group had varying degrees of decreased restrictive ventilation function, small airway function and gas exchange function parameters (P<0.05). Correlation analysis showed that, as the GK Angle increases, the left atrioventricular cavity size (LAD, LVDD, LVSD) and diastolic function parameters (E/A, e’/a’) gradually decreased, showing a significant negative correlation (P<0.05); There was a significant negative correlation between GK angle and parameters of pulmonary restrictive ventilation function (P<0.05).Conclusions GK angle of AS patients has certain influence on cardiopulmonary function. The larger the GK angle is, the smaller the atrioventricular cavity diameter is, and the worse the left ventricular diastolic function is. At the same time, the results showed that the larger the GK angle was, the worse the corresponding pulmonary function of patients was.
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