Correlation between serum C-reactive protein and Interleukin-6 levels and depressive in elderly patients with mild vascular cognitive impairment
QUAN Qingyun1, YU Li2, HUANG He1
1. Wards for Offices, Shaanxi Provincial Corps Hospital of Chinese People’s Armed Police Force, Xi’an 710054, China; 2. Outpatient Department of Armed Police Corps Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830018,China
Abstract：Objective To investigate the association between depression and the serum C-reactive protein and Interleukin-6 in elderly patients with mild vascular cognitive impairment (mVCI).Methods Case-control studies were used. A total of 82 elderly patients with mild vascular cognitive impairment were enrolled in Shaanxi Provincial Corps Hospital of Chinese People’s Armed Police Force from March 2021 to June 2022. According to the testing standard score of Self-Rating Depression Scale, the patients were divided into 2 groups of the depressed mood group and the no-depressed mood group. During the same period, 76 people with normal physical examination results in physical examination center were classified into the control group. The serum CRP and IL-6 levels were detected and the data were analyzed statistically.Results The serum CRP levels in the case group and in the control group were respectively(7.16±2.57)mg/L and(4.28±2.11)mg/L,IL-6 were respectively(7.43±1.81)pg/ml and(5.31±1.67)pg/ml, and there were statistical differences between the two groups(t=-7.664,P＜0.001;t=-7.688,P＜0.001).The serum CRP levels in the depressed group and in the control group were respectively(7.41±2.34)mg/L and(6.10±2.13)mg/L,IL-6 were respectively(7.67±1.76)pg/ml and(6.90±1.35)pg/ml, and there were also statistical differences between the two groups(t=2.642,P＜0.05;t=2.205,P＜0.05).Conclusions For elderly mVCI patients, attention should be paid to monitoring the levels of CRP and IL-6, which has certain guiding significance for the early diagnosis and intervention of patients with obscure depressive mood.
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2023, Vol. 34 
