胰岛素两种给药方式对妊娠糖尿病疗效的比较

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (643 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the difference of therapeutic effects between the insulin pump and direct injection of insulin when used for patients with gestational diabetes mellitus (GDM).Methods 162 patients of gestational diabetes mellitus (GDM) were selected as subjects who were divided into the insulin pump group and the direct injection of insulin group, respectively. The related indicators were monitored by the continuous blood sugar monitoring system and other testing methods when the patients were treated with different therapeutic schemes. The experimental data was analyzed by SPSS 17.0 software.Results After treatment, most indicators of blood glucose, blood lipid and peptide-C in GDM patients were significantly reduced (P<0.05). Moreover,such indicators as peptide-C, HbA₁c (%), FPG,2hPG, MAGE and MODD of the insulin pump group were significant lower than those in the direct injection of insulin group after treatment(P<0.05). The relative deviation of indicators was less in the insulin pump group than in the direct injection of insulin group. The insulin pump group had less glycemia variability, but a significantly higher score of quality of life than the direct injection of insulin group(P<0.05).Conclusions The insulin pump has a better therapeutic effect for GDM patients than direct injection of insulin while helping to maintain an ideal level of blood glucose.

Key words： gestational diabetes mellitus blood glucose glycemic excursion continuous glucose monitoring system (CGMS) insulin pump, quality of life

Received: 20 November 2016

ZTFLH:

R587.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I5/483

[1]	Castorino K, Paband R, Zisser H, et al. Insulin pumps in pregnancy: using technology to achieve normoglycemia in women with diabetes[J]. Curr Diab Rep, 2012, 12(1): 53-59.
[2]	Mazze R, Yogev Y, Langer O. Measuring glucose exposure and variability using continuous glucose monitoring in normal and abnormal glucose metabolism in pregnancy[J]. J Matern Fetal Neonatal Med, 2012, 25(7): 1171-1175.
[3]	Sartore G, Chilelli N C, Burlina S, et al. Association between glucose variability as assessed by continuous glucose monitoring (CGM) and diabetic retinopathy in type 1 and type 2 diabetes[J]. Acta diabetol, 2013, 50(3): 437-442.
[4]	姚毓筠. 胰岛素泵治疗妊娠糖尿病的临床疗效分析[J]. 检验医学与临床,2013,10(16):2108-2109.
[5]	陈彬,吕肖锋,焦秀敏,等. 动态胰岛素泵对2型糖尿病患者血糖波动控制的效果[J] .解放军医药杂志,2013,25(9):52-54.
[6]	Kallas-Koeman M M, Kong J M, Klinke J A, et al. Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes[J]. Diabetologia, 2014, 57(4): 681-689.
[7]	苏可.用动态血糖监测系统与胰岛素泵联合治疗控制血糖的疗效[J]. 糖尿病天地·临床(下旬), 2010,4(5):220-221.
[8]	Combs C A. Continuous glucose monitoring and insulin pump therapy for diabetes in pregnancy[J]. J Matern Fetal Neonatal Med, 2012, 25(10): 2025-2027.
[9]	吴静,薛耀明,李晨钟,等. 利用动态血糖监测系统观察妊娠糖尿病患者孕中晚期的血糖漂移[J] .中国糖尿病杂志,2010,18(6):449-451.
[10]	张楠,叶水文,刘东方. 动态血糖监测在妊娠糖尿病低血糖事件中的运用[J]. 实验与检验医学,2013,31(2):133-134, 145.
[11]	Yu F, Weng J, Lv L et al. Continuous glucose monitoring effects on maternal glycemic control and pregnancy outcomes in patients with gestational diabetes mellitus: a prospective cohort study[J]. J Clin Endocrinol Metab, 2014, 99 (12): 4674.
[12]	周丽. 双C方案治疗妊娠糖尿病的临床观察[J] . 中国现代医生,2014,52(4):133-135.
[13]	Su J B, Wang X Q, Chen J F, et al. Glycemic variability in gestational diabetes mellitus and its association with beta cell function[J]. Endocrine, 2013, 43(2): 370-375.
[14]	杜同信,王自正. 妊娠期糖尿病患者胰岛素和C肽兴奋水平的测定[J]. 标记免疫分析与临床, 2001,8(4):207-209.
[15]	Vejrazkova D, Lukasova P, Vankova M, et al. MTNR1B genetic variability is associated with gestational diabetes in Czech women[J]. Int J Endocrinol, 2014, 57(7): 448.
[16]	毕汇文,张新亚,李坚. 妊娠期糖尿病与正常妊娠血脂、胰岛素、C肽的对照分析[J]. 中国妇幼保健,2008,23(31):4400-4401.