老年人长期服用阿司匹林与胃黏膜组织状态、幽门螺杆菌感染率的关系分析

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Abstract Objective To study the relationships between chronic use of aspirin and gastric mucosa tissue state,Helicobacter pylori infection rate among elderly patients.Methods Sixty-eight elderly patients treated with aspirin at our hospital between January 2015 and December 2016 were selected as the observation group,while another 68 middle-aged patients treated at the same time served as the control group.The Helicobacter pylori infection rates,gastric mucosa blood flow and gastric mucosa tissue oxidative stress indexes of two groups with different durations of medication were analyzed and compared,so were the detection Results of patients in the observation group who took aspirin for different lengths of time.Results The Helicobacter pylori infection rate of observation group (63.24%) was significantly higher than that of control group (38.24%), and the infection rates of patients with different durations of medication were higher than those of control group. Specifically, the infection rate of patients in observation group (52.63%) who had taken the drug less than 5 years was significantly higher than that of control group (28.95%), and the infection rate of patients in observation group (76.67%) who had taken the drug more than 5 years was also significantly higher than that of control group (50.00%). The gastric mucosa blood flow of the greater curvature, lesser curvature, anterior gastric wall, and posterior gastric wall of observation group was lower than that of control group regardless of the duration of medication. Similarly, among the gastric mucosa tissue oxidative stress indexes, SOD (superoxide dismutase) level was much lower than that of control group, while the levels of NO (nitric oxide) and MDA (Methylene dioxyamphetamine) were both higher than those of control group. Besides, the detection Results of all these indexes in the observation group with different durations of medication were significantly different (P<0.05).Conclusions Chronic use of aspirin by elderly patients can lead to a worse state of gastric mucosa and a higher Helicobacter pylori infection rate,so targeted intervention is needed.

Key words： elderly patients chronic use of aspirin gastric mucosa tissue state Helicobacter pylori infection rate

Received: 28 August 2017

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	LUO Yanjie
	WANG Xiaohui
	LI Yuqi
	ZHANG Kunlong
	DENG Jing

Cite this article:

LUO Yanjie,WANG Xiaohui,LI Yuqi等. Relationships between chronic use of aspirin and gastric mucosa tissue state and Helicobacter pylori infection rate among elderly patients[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(12): 1256-1259.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I12/1256

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