阿托伐他汀联合银杏叶对脑梗死患者脑血流参数和颈动脉粥样硬化斑块的影响

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Abstract Objective To investigate the effect of atovastatin and ginkgo biloba preparations on cerebral blood flow parameters and carotid atherosclerotic plaque indexes in patients with cerebral infarction.Methods Two hundred and thirty-five patients with cerebral infarction were selected in our hospital. The patients were divided into two groups according to the drug regimen. The control group (n=116) was treated with atovastatin while the experimental group (n=119) was additionally given ginkgo biloba preparations. The changes of carotid atherosclerotic plaques, cerebral hemodynamic parameters and hemorheological indexes were compared before and after treatment. Adverse reactions were also recorded.Results In the experimental group, the hemodynamic indexes RI(0.52±0.17) and PI(0.91±0.24) were significantly lower than in the control group, while Vd(37.29±2.82)cm/s, Vs(81.33±3.58)cm/s and Vm(9.78±1.22) cm/s were significantly higher (P＜0.05). In the experimental group, the plaque area of posterior carotid atherosclerosis (0.52±0.12)cm², CAIMT(1.26±0.17)mm was significantly smaller than that of the control group (P＜0.05) after treatment. There was no significant difference in the rate of adverse reactions between the two groups.Conclusions For patients with cerebral infarction, atovastatin combined with ginkgo biloba preparations can effectively promote the recovery of hemorheological indexes and hemodynamic parameters and improve carotid atherosclerotic plaques. This approach is quite safe.

Key words： atovastatin ginkgo biloba preparation cerebral infarction cerebral blood flow parameter carotid atherosclerotic plaque index

Received: 09 February 2018

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R364.17

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	Articles by authors
	SONG Bo
	SUN Yukun
	HE Wei
	SONG Yang
	TANG Zhe
	ZHU Hongxia
	WANG Haipeng
	and SU Hong

Cite this article:

SONG Bo,SUN Yukun,HE Wei等. Effects of atovastatin and ginkgo biloba preparations on cerebral blood flow parameters and carotid atherosclerotic plaque indexes in patients with cerebral infarction[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(5): 500-503.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I5/500

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