慢性阻塞性肺疾病患者胸大肌CT参数与肺功能及疾病严重程度的关系

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Abstract Objective To analyze the relationship between pectoral major muscle area (PMA) and pectoral major muscle density (PMD) measured by computed tomography (CT) and lung function and disease severity in patients with chronic obstructive pulmonary disease (COPD) based on generalized linear model. Methods Clinical data of 293 COPD patients admitted to the 910th Hospital of PLA Joint Logistics Support Force from January 2021 to December 2023 were retrospectively collected. PMA and PMD were measured based on axial images above the aortic arch on chest CT. Generalized linear models were used to analyze the correlation between PMA and PMD and parameters of lung function and disease severity. Results Compared with the high PMA group, the low PMA group had lower forced vital capacity (FVC), FVC as a percentage of the predicted value, forced expiratory volume in one second (FEV₁), FEV₁ as a percentage of the predicted value, and FEV₁/FVC ratio (P<0.05), but higher CAT scores and emphysema index (P<0.05). For every 10 cm² increase in PMA, there was a 0.17L increase in FVC, a 4.47% increase in FVC as a percentage of the predicted value, a 0.21 L increase in FEV₁, an 8.02% increase in FEV₁ as a percentage of the predicted value, a 0.04 increase in FEV₁/FVC ratio, and a 2.58% decrease in emphysema index. Compared with the high PMD group, the low PMD group had lower FVC as a percentage of the predicted value, FEV₁ as a percentage of the predicted value, and FEV₁/FVC ratio (P<0.05), but a higher emphysema index (P=0.007). For every 10 HU increase in PMD, there was a 4.64% increase in FVC as a percentage of the predicted value, a 0.14 L increase in FEV₁, an 8.56% increase in FEV1 as a percentage of the estimated value, and a 0.04 increase in FEV₁/FVC ratio (P<0.05). Conclusions PMA and PMD measured by CT are correlated with disease severity and lung function in COPD patients, and can be used as parameters to evaluate disease severity in patients.

Key words： chronic obstructive pulmonary disease pectoralis major muscle CT lung function

Received: 22 January 2024

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	Articles by authors
	HONG Liyue
	HUANG Zhongjie
	HUANG Xincheng
	HUANG Wencheng
	GUO Zhixiong
	HONG Yuancheng

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HONG Liyue,HUANG Zhongjie,HUANG Xincheng等. Relationship between pectoralis major muscle CT parameters and lung function and disease severity in patients with chronic obstructive pulmonary disease[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(7): 582-587.

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https://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR https://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2024/V35/I7/582

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