1. Department of Endocrinology, The 309th Hospital of PLA, Beijing 100091, China;
2. District Center for Disease Control and Prevention, Chinese People’s Armed Police Forces, Beijing 102613, China;
3. Department of Endocrinology,Xijing Hospital, The Fourth Military Medical University, Xi’an 710038, China
Abstract：Objective To analyze 18 principal clinical indicators of renal function in patients with type 2 diabetic nephropathy(DN) and to explore a superior evaluation index. Methods 171 DN patients were recruited. Variation and correlation analysis of 18 clinical indexes was conducted, the SCr, BUN, B-beta 2-, U - beta 2-MG, MG, U-U-propagated, U-IgG alpha 1-MG, UA and GFR as nine optimal indicators were selected. Statistical software SAS was used for analysis of principal components. Results With eigenvalues greater than 1 as the principle, three principal components were extracted from the rootie 3.557, 1.403, and 1.007, respectively its the cumulative variance contribution rate was 66.294%. Since the selected three principal components of the cumulative contribution rate had yet to reach more than 85%, 3 principal components were added, thereby the cumulative contribution rate reaching 89.274%. Conclusions Of nine clinical indicators, associated with renal function in patients with type 2 diabetes, the six principal components can reflect most of the information. Based on the degree of variation, correlation and factor loading of principal component evaluation, SCr, BUN, and U-IgG superior evaluation indexes for renal function evaluation in patients with type 2 diabetes.
贾晓炜,栾进,张南雁,李岚,赵琳,贾贺堂. 2型糖尿病肾病患者肾功能相关指标的主成分分析[J]. 武警医学, 2013, 24(7): 597-599.
JIA Xiaowei,LUAN Jin,ZHANG Nanyan,LI Lan,ZHAO Lin,and JIA Hetang.. Analysis of principal component of relevant parameters of renal function in patients with type 2 diabetes. Med. J. Chin. Peop. Armed Poli. Forc., 2013, 24(7): 597-599.
Liu L, Zhang T, Wang F, et al. Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropafhy in Chinese type 2 diabetic patients [J]. Diabetes Care, 2010, 33: 144-149.
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2013, Vol. 24 
