Effect of Liqi Huoxue drop pills on clinical symptoms, emotional state,recurrence rate, long-term quality of life, serum CRP, TNF- alpha and IL-6 levels in patients with coronary heart disease and angina pectoris
WANG Siming1, LIU Ming2
1.Department of Endocrinology, No. 107 Hospital of PLA, Yantai 264002,China; 2.Department of Endocrinology, No. 401 Hospital of PLA, Qingdao 266071, China
Abstract：Objective To analyze the effect of Liqi Huoxue (qi-regulating and blood-activating) drop pills on the improvement of clinical symptoms, emotional state, recurrence rate, long-term quality of life, serum CRP, TNF- alpha and IL-6 levels in patients with coronary heart disease (CHD).Methods Ninety-four patients with angina pectoris treated between April 2014 and August 2016 were randomly divided into the control group and the observation group, with 47 cases in each. The control group received conventional treatment, while the observation group was additionally treated with Liqi Huoxue drop pills. The course of treatment lasted for 4 weeks, and follow-up went on for more than 6 months.Improvement of clinical symptoms, recurrence rate, long-term quality of life, and serum CRP, TNF- alpha and IL-6 levels before and after treatment were compared between the two groups.Results After treatment, the total effective rate was 82.98% in the control group and the recurrence rate was 19.15% in the follow-up period, compared with 97.87% and 4.26% in the observation group. There was statistically significant difference between the two groups (P<0.05).There was no significant difference in HAMD scores or SF-36 scores between the two groups before treatment. Six months after treatment, the HAMD score of the observation group was lower than that of the control group, but the SF-36 score was higher than that of the control group, and there was statistically significant difference between the two groups (P<0.05). Serum CRP, TNF- alpha and IL-6 levels were not significantly different between the two groups of patients before treatment.However, after treatment, these levels were lower in the observation group than in the control group, and there was significant difference between the two groups (P<0.05). The rate of adverse reactions of the control group was 10.64% during the treatment, compared with 14.89% in the observation group, and there was no significant difference between the two groups.Conclusions Liqi Huoxue dropping pills, when used as an adjunctive therapy for coronary heart disease and angina pectoris, helps relieve the clinical symptoms of the patients, reduce the risk of recurrence, and improve the long-term quality of life of patients. Reducing the level of serum inflammatory factors may be one of the mechanisms by which these pills can help treat coronary heart disease and angina pectoris.
王思明, 刘敏. 理气活血滴丸对冠心病心绞痛的疗效及对患者情绪状态、血清CRP、TNF-α、IL-6水平的影响[J]. 武警医学, 2018, 29(8): 770-773.
WANG Siming, LIU Ming. Effect of Liqi Huoxue drop pills on clinical symptoms, emotional state,recurrence rate, long-term quality of life, serum CRP, TNF- alpha and IL-6 levels in patients with coronary heart disease and angina pectoris. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(8): 770-773.
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2018, Vol. 29 
