Correlations between total bilirubin and thyroxine among euthyroid patients with newly diagnosed type 2 diabetes mellitus
CHEN Xiaojun1, ZEN Jian1, KOU Xuemei2
1.Department of Endocrinology, Fujian Provincial Corps Hospital of Chinese People’s Armed Police Force, Fuzhou, 350003 China; 2.Department of Pathology,Beijing Municipal Corps Hospital of Chinese People's Armed Police Force,Beijing 100027,China
Abstract：Objective To investigate the correlations between total bilirubin and thyroxine among euthyroid patients with newly diagnosed type 2 diabetes mellitus.Methods A total of 280 newly diagnosed patients with type 2 diabetes mellitus and another 276 healthy people were selected. The correlations between thyroxine and total bilirubin were analyzed.Results Bilirubin was positively correlated with free T3 in 280 T2DM subjects (r=0.512, P<0.01), but free thyroid and thyroid-stimulating hormone were not. Such correlations were not found in 276 non-diabetic subjects (r=0.086, P>0.05). During multiple linear regression analysis, free T3 was found to interact positively with the presence of HbA1c on serum bilirubin (interaction term: β=0.244, P=0.01). This interaction remained present after additional adjustment for alcohol intake, aspartate transaminase, insulin sensitivity, cholesterol, triglycerides, BMI and fasting insulin.Conclusions Low bilirubin is related to low free T3 levels in euthyroid and newly diagnosed diabetic subjects, The relationship can be modified by HbA1c. It is the possible mechanism of high atherosclerosis in newly diagnosed patients type 2 diabetes with high HbA1c.
陈晓军, 曾建, 寇雪梅. 甲状腺功能正常的初诊2型糖尿病患者血总胆红素与甲状腺激素水平的相关性[J]. 武警医学, 2019, 30(9): 769-771.
CHEN Xiaojun, ZEN Jian, KOU Xuemei. Correlations between total bilirubin and thyroxine among euthyroid patients with newly diagnosed type 2 diabetes mellitus. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(9): 769-771.
SarfoKantanka O, Sarfo F S, Ansah E O, et al. The Effect of Thyroid Dysfunction on theCardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana [J]. J Diabetes Res, 2018,18: 1-8.
[2]
Ozeki M, Morita H, Miyamura M, et al. High serum bilirubin is associated with lower prevalence of peripheral arterial disease among cardiac patients[J]. Clin Chim Acta, 2018,476: 60-66.
[3]
Zhu P, Liu X, Mao X. Thyroid-Stimulating hormone levels are positively associated with insulin resistance[J]. Med Sci Monit, 2018,17:342-347.
[4]
Wang C. The Relationship between type 2 diabetes mellitus and related thyroid diseases[J]. J Diabetes Res, 2013,13:1-9.
[5]
Zou J, Tian F, Zhang Y, et al. Association between thyroid hormone levels and diabetic kidney disease in euthyroid patients with type 2 diabetes[J].Sci Rep, 2018,16: 4728-4737.
[6]
Xu L, Lei Z, Haibing C, et al. Relationship between serum bilirubin concentrations and diabetic nephropathy in Shanghai Han’s patients with type 1 diabetes mellitus[J]. BMC Nephrol, 2017,18: 114-121.
[7]
Deetman P E, Kwakernaak A J, Bakker S J, et al. Low-Normal free thyroxine confers decreased serum bilirubin in type 2 diabetes mellitus[J]. Thyroid, 2013,23: 1367-1373.
[8]
Petronella E, Bakker S L, Kwakernaak A J, et al. The relationship of the anti-Oxidant bilirubin with free thyroxine is modified by insulin resistance in euthyroid subjects[J]. PLoS One, 2014,9: 90886-90892.
[9]
Brian F, Christoffer C, Zhimeng Z, et al. Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease[J]. Cell, 2016,167:843-857.
[10]
Bruinstroop E, Dalan R, Yang C, et al. Low dose levothyroxine reduces intrahepatic lipid content in patients with type 2 diabetes mellitus and NAFLD[J]. J Clin Endocrinol Metab, 2018,27:2698-2706.
2019, Vol. 30 
