Effect of homocysteine on patients with vascular cognitive impairment
LIU Lijun1, HAN Zhiqun2, DENG Xin3
1. Department of Internal Medicine, Outpatient Department, Department of Ministry,Beijing 100701,China; 2. Emergency Department of Jingdong Medical District, PLA General Hospital,Beijing 101149,China; 3. Department of Neurology,Third Medical Center of Chinese PLA General Hospital,Beijing 100039,China
Abstract：Objective To find out whether reducing homocysteine (Hcy) levels can delay the cognitive decline in patients with vascular encephalopathy and cognitive impairment. Methods Between July 2015 and June 2018, 77 patients with vascular encephalopathy and cognitive impairment were selected. According to the Hcy level of patients, 45 patients were assigned to the normal group and 32 to the elevation group. After 6, 12 and 18 months of treatment, the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)were carried out in the two groups respectively. The results of both types of examination were analyzed to evaluate the change of patients' cognitive impairment. Results The decrease rate of the MMSE score in the normal group was significantly lower than that in the elevation group (P<0.05). The MOCA scores of the two groups decreased at 6, 12 and 18 months after treatment, but the scores of orientation, delayed recall, visual perception, naming, attention and total scores of the normal group were higher than those of the elevation group, and the decrease rate was slower. The difference was statistically significant (P<0.05). Conclusions Lowering Hcy levels to normal can slow down the development of cognitive impairment in patients with vascular encephalopathy and cognitive impairment, and the treatment with folic acid and B vitamins can also slow down cognitive impairment.
刘丽君, 韩智群, 邓馨. 同型半胱氨酸对血管性认知障碍患者的影响[J]. 武警医学, 2020, 31(6): 483-485.
LIU Lijun, HAN Zhiqun, DENG Xin. Effect of homocysteine on patients with vascular cognitive impairment. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(6): 483-485.
Hyuk S K ,Dongwhane L M, Hwan L, et al. Post stroke cognitive impairment as an independent predictor of ischemic stroke recurrence: PICASSO substudy[J]. J Neurology,2020,267(3):688-693.
2020, Vol. 31 
