Objective To analyze the efficacy and safety of CT-assisted soft channel drainage in the treatment of ventricular hemorrhage (IVH). Methods The clinical medical records of IVH patients who were admitted to the Neurosurgery Department of the Third Hospital of Xingtai City from February 2017 to September 2021, were retrospectively analyzed. According to surgical methods, the patients were divided into group A (n=46, conventional craniotomy for hematoma evacuation) and group B (n=46, CT-assisted soft channel drainage).The clinical treatment effect, operation time, hematoma clearance time, hospital stay, blood loss of 7 days after operation, hematoma clearance rate and postoperative complications were compared between the two groups. The patients were followed up for 6 months after the operation, and the activities of daily living (ADL) and modified Rankin Scale (mRS) were used to evaluate the degree of neurological recovery and recent recovery of patients. Results The clinical efficacy of group B was better than that of group A (89.13% vs. 71.39%,P<0.05), the incidence of postoperative complications was lower than that of group A(P<0.05), and the operation time, hematoma removal time and hospital stay in group B were shorter than those in group A(P＜0.05),the intraoperative blood loss was less than that of group A (P＜0.05);The first hematoma clearance rate was lower than that of group A and there was no significant difference in the hematoma clearance rate between the two groups at the time of extubation; the mRS, ADL score of group B was lower than those of group A (P＜0.05). Conclusions CT-assisted soft channel drainage for IVH can achieve good results, with less trauma and high safety, and significantly improves the near-term prognosis of patients.