Evaluation of an alternative medicinal administration method by mixing multiple vasoactive drugs in vitro among elderly and the critically ill patients
GUO Yan1, SHI Haiyan2, MA Xiao2, WANG Lu1, MA Yawei1
1. Department of Cardiology,2. Gastroenterology, Second Medical Center of PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing 100853,China
Abstract：Objective To evaluate the clinical effect of the in vitro simulation premixed method during the maintenance of hemodynamic stability when multiple vasoactive drugs are replaced among elderly and critically ill patients. Methods Between June 2016 and October 2020, 98 elderly and critically ill patients in our hospital were randomly divided into the premixed group and control group, with 49 cases in each. In the control group, venous fluid and vasoactive drugs were correctly arranged and connected with the three-way connector, the old tube was removed after connecting the extension tube for exhaust, and the new tube was connected with the venous catheter. In the premixed group, the in vitro simulation premixed method was adopted, which involved connecting and running the micro pump to premix the drug for 3 minutes before replacing the tube. Blood pressure and heart rate were measured before tube replacement and 1 min, 3 min, 5 min and 10 min after replacement in the two groups. The fluctuations and recovery time of blood pressure, heart rate before and after replacement were recorded for three consecutive days. Results There were significant differences in systolic blood pressure at 3 min,5 min,10 min after replacement[(15.55±5.59)mmHg,(6.59±1.74)mmHg and(5.02±1.51)mmHg]in the premixed group versus[(47.02±6.36)mmHg,(25.51±5.60)mmHg and(10.69±4.10)mmHg]in the control group. There was no significant difference between the two groups at 1 min after replacement, but there was significant difference at 3 min, 5 min and 10 min after replacement. Conclusions The in vitro simulation premixed method, when used to replace the infusion tube for the elderly and critically ill patients treated with vasoactive drugs, can effectively reduce the fluctuations of blood pressure and heart rate, shorten the recovery time of blood pressure and heart rate after tube replacement, and maintain the stability of hemodynamics.
郭妍, 石海燕, 马骁, 王璐, 马雅维. 体外模拟预混法应用于老年危重患者血管活性药物管路更换的临床效果[J]. 武警医学, 2022, 33(3): 215-218.
GUO Yan, SHI Haiyan, MA Xiao, WANG Lu, MA Yawei. Evaluation of an alternative medicinal administration method by mixing multiple vasoactive drugs in vitro among elderly and the critically ill patients. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(3): 215-218.
2022, Vol. 33 
