Abstract：Objective To investigate the correlations between the morning blood pressure surge(MBPS) and target organ damage in patients with hypertension and impaired glucose tolerance.Methods Two hundred and ten primary hypertension patients with impaired glucose tolerance(IGT) were divided into the MBPS group (n=100) and non-MBPS group (n=110). The carotid intima-media thickness (IMT), carotid artery plaque (CA), left ventricular hypertrophy and hypertension fundus artery lesions, and urinary albumin/creatinine (MAU) were determined to assess the target organ damage by MBPS.Results The 24 h mean systolic blood pressure [(136.24±10.59) mmHg], daytime systolic blood pressure [(140.32±12.09) mmHg]and diastolic blood pressure [(86.7±9.40) mmHg], IVST [(12.2±1.4)mm], VPWT[(12.6±2.7)mm], LVEDD[(54.2±7.6)mm], LVMI[(147.2±29.8) g/m2),and IM [(1.28±0.32)mm)were all higher in the MBPS group than in the non-MBPS group. The detection rates of carotid plaque (47.0%), left ventricular hypertrophy (44.0%)and hypertensive fundus lesions (63.0%) in the MBPS group were significantly higher than those of the non-MBPS group (33.0%, 27.3%, 46.4%).Conclusions For patients with hypertension with reduced glucose tolerance, MBPS can lead to the increase of IVST, LVPWT, LVEDD, LVMI, IMT, left ventricular hypertrophy and the incidence of hypertensive fundus lesions. Therefore, measures should be taken to control the MBPS in patients with hypertension complicated with IGT.
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