L<sub>3</sub>骨骼肌指数在胰腺炎病程进展中的诊断价值

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摘要目的探讨L₃骨骼肌指数(L₃SMI)在胰腺炎病程进展中的应用价值。方法选择2020-08至2023-08武警广东总队医院就诊的146例胰腺炎患者,选择同期79名健康体检者作为对照组。所有参与者均进行CT检查测定L₃SMI。采用酶联免疫吸附实验测量血清中白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-C趋化因子配体2(CCL2)和瘦素水平并建立四元线性回归模型,以排除可能的混杂因素。结果在调整模型后,L₃SMI指数在对照组,首次胰腺炎(FAP)组患者、复发性急性胰腺炎(RAP)患者以及慢性胰腺炎(CP)组患者中呈显著降低趋势(P趋势分别为0.005、0.019和0.020)。在所有模型中,瘦素与L₃SMI显著负相关(模型1:β=-0.005,P=0.021;模型2:β=-0.004,P=0.044;模型3:β=-0.003,P=0.063;模型4:β=-0.004,P=0.054),其他因子与L₃SMI无显著相关性。结论 L₃SMI在从FAP到RAP再到CP的连续过程中逐渐减少,瘦素的变化水平可能是其中的一个重要影响因素。

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	成赋斌
	杨先文
	李龙

关键词 ： L₃骨骼肌指数, 胰腺炎, 瘦素

Abstract：Objective To investigate the application value of L₃ skeletal muscle index (L₃SMI) in the progression of pancreatitis. Methods A total of 146 patients with pancreatitis and 143 healthy people from August 2020 to August 2023 at Guangdong Provincial Corps Hospital of Chinese People's Armed Police Force were included in this study. All participants underwent CT examination to determine L₃SMI. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-C chemokine ligand 2 (CCL2) and leptin were measured by enzyme-linked immunosorbent assay(ELISA), and a four-element linear regression model was established to exclude possible confounding factors. Results After adjusting the model, the L₃SMI index showed a significant decreasing trend in the control group, first-time pancreatitis(FAP) group, recurrent acute pancreatitis(RAP) group, and chronic pancreatitis(CP) group (p-trends of 0.005, 0.019, and 0.020, respectively). Leptin was significantly negatively correlated with L₃SMI in all models (Model 1: β=-0.005, P=0.021; Model 2: β=-0.004,P=0.044; Model 3: β=-0.003, P=0.063; Model4: β=-0.004, P=0.054). There was no significant correlation between other factors and L₃SMI. Conclusions L₃SMI decreases gradually during the continuous process from FAP to RAP and CP, and the changes of leptin level may be an important influencing factor.

Key words： L₃ skeletal muscle index pancreatitis leptin

收稿日期: 2024-10-31

ZTFLH:	R576
	R445

作者简介: 成赋斌,本科学历,副主任医师。

引用本文:

成赋斌, 杨先文, 李龙. L₃骨骼肌指数在胰腺炎病程进展中的诊断价值[J]. 武警医学, 2025, 36(3): 214-218. CHENG Fubin, YANG Xianwen, LI Long. Diagnostic value of L₃ skeletal muscle index in the progression of pancreatitis. Med. J. Chin. Peop. Armed Poli. Forc., 2025, 36(3): 214-218.

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https://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 https://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2025/V36/I3/214

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