Abstract：Objective To explore the clinical characteristics and prognostic factors of pneumococcal meningitis in different age groups.Methods The clinical data on 124 patients with pneumococcal meningitis who had been hospitalized in our hospital and confirmed by pathology between June 2015 and June 2016 was retrospectively analyzed. These patients were divided into three groups: Group A (under one year old), Group B (1 to 5 years old) and Group C (above 5 years old). The clinical characteristics of the three groups were compared. According to the Glasgow prognosis score, the prognostic factors of these children were analyzed by single factor and logistic regression analysis.Results All the 124 cases showed different degrees of fever. The incidence of high fontanelle tension and convulsion in Group A was significantly higher than that in the other groups. The incidence of coma and fuzzy consciousness in Group B was significantly higher than that in the other two groups (P<0.05), and the incidence of headache and vomiting was significantly higher in Group C than in the other two groups (P<0.05). The incidence of complications was 91.2% (73/80)in Group A, 65.2%(15/23) in Group B and 28.6%(6/21)in Group C. The incidence of complications was significantly higher in Group A than in the other two groups. Logistic regression analysis showed that age less than 1 year old, elevated c-reactive protein, and lower levels of cerebrospinal fluid glucose, blood sodium, blood calcium, and serum protein were independent factors that affected the prognosis of pneumococcal meningitis.Conclusions Boys under one year old are more vulnerable to pneumococcal meningitis. Age under one year old, c-reactive protein above 100 mg/L, hyponatremia, and low blood calcium are the factors affecting the prognosis of the disease.
赵国光, 聂军红, 杨丽. 不同年龄组小儿肺炎链球菌性脑膜炎临床特征及预后影响因素调查[J]. 武警医学, 2018, 29(3): 229-232.
ZHAO Guoguang, NIE Junhong, YANG Li. Clinical characteristics and prognostic factors of pneumococcal meningitis in different age groups. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(3): 229-232.
2018, Vol. 29 
