Relationship between genetic polymorphism of EDN1 gene and diabetic nephropathy
LI Diangeng1, GUO Yujie1, JIN Meiling2, GAO Lingling3, CHEN Youli4
1. Department of Academic Research, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing 100015, China; 2. Department of Nephrology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China; 3. Department of Internal medicine, General Hospital of Huabei Petroleum Administration Bureau,Renqiu 062552,China; 4. Effice infirmary, Comprehensive Assurance Certer, Standing Committee of Beijing Municipal People’s Congress, Beijing 101100, China
Abstract：Objective To investigate the effect of genetic polymorphism of EDN1 gene on the incidence of type 2 diabetic nephropathy among the Han nationality in northern China. Methods This study involved 120 Han population, including 60 patients with type 2 diabetic nephropathy and 60 patients with type 2 diabetes but without nephropathy matched by sex and age. Polymorphisms of EDN1 rs5370 locus were detected using polymerase chain reaction (PCR) techniques. Results Serum levels of total cholesterol, triglycerides, low-density lipoprotein, creatinine and uric acid were notably elevated in the diabetic nephropathy group compared with the non-nephropathy diabetes group. There was a significant difference in the distribution of the EDN1 rs5370 alleles between the groups. Individuals with T/T genotype had a significantly lower risk of diabetic nephropathy compared to those with G/G genotype [OR=0.357, 95%CI(0.132-0.963), P=0.042]. Additionally, individuals with T allele had a significantly lower risk of diabetic nephropathy compared to those with G allele [OR=0.565, 95%CI(0.339-0.942), P=0.029]. Conclusions The rs5370 polymorphism of EDN1 gene may be associated with the risk of type 2 diabetic nephropathy, especially the T allele may offer a protective effect. These findings provide important insights into the genetic mechanisms of diabetic nephropathy and may influence future strategies for prevention and treatment.
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2024, Vol. 35 
