Abstract：Objective To investigate the application value of multi-modal analgesia strategy in the treatment of traumatic orthopedic patients. Methods A total of 94 orthopedic traumatic patients treated at General Hospital of PLA Central Theater Command from November 2022 to November 2023 were selected, divided into a multi-modal group (given multi-modal analgesia strategy, n=48) and a control group (given conventional pain management, n=46) and according to the random number table method. Visual analogue scale (VAS) score, Ramsay sedation score, diastolic blood pressure (DBP), and systolic blood pressure (SBP) were compared at admission (T0), before surgery (T1), 1 d after surgery (T2), 2 d after surgery (T3), and at discharge (T4). Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were compared at time points of T0, T1, T3 time points, and the length of hospital stay, first time of PCA pump compression after surgery, total number of PCA pump compressions and adverse reactions were also compared. Results Compared with the control group, the VAS scores at T1, T2, T3 and T4 [(3.56±0.74) points, (2.17±0.91) points, (1.48±0.50) points and (0.96±0.29) points] significantly decreased in multi-modal group (P<0. 05). Compared with the control group, the levels of IL-6[(78.53±11.75) pg/ml and (40.55±8.57) pg/ml], TNF-α[(73.46±12.08) pg/ml and (38.88±8.06) pg/ml] at T1 and T3 significantly decreased in the multi-modal group. The difference was statistically significant (P<0. 05). Compared with the control group, the Ramsay sedation scores [2.00 (1.00, 2.00)],[4.00(4.00,4.00)] and [3.00(3.00, 4.00)] at T1, T2 and T3 significantly increased in the multi-modal group, and the differences were statistically significant (P<0.05). The SBP and DBP of T1, T2, T3 and T4 in multi-modal group were significantly lower than those in the control group (P<0.05). Compared with the control group, the first time of PCA pump compression in the multi-modal group was longer, the total number of PCA pump compression was lower, the total satisfaction was higher, and the incidence of adverse reactions was lower (22.92% vs 60.87%), with statistical significance (P<0.05). Conclusions Multi-modal analgesia strategy is beneficial to reduce perioperative pain and inflammatory response, make hemodynamics more stable and improve patient experience in orthopedic traumatic patients.
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2025, Vol. 36 
