Characteristics and risk factors of cefoperazone/sulbactam related coagulation dysfunction in neurosurgery patients
JIN Xing1, LU Xiaoyun1, LI Yamei2
1. Department of Disease Control and Prevention, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China; 2. Department of Pharmacy, Xi'an No.1 Hospital, Xi’an 710002, China
AbstractObjective To analyze the characteristics and risk factors of cefoperazone/sulbactam related coagulation dysfunction in neurosurgery patients. Methods A retrospective study was carried out on the neurosurgery patients treated with cefoperazone/sulbactam in the Neurosurgery Department of Xijing Hospital of Air Force Military Medical University from January 2020 to February 2023. The patients were divided into normal group and abnormal group according to whether there was coagulation dysfunction after medication. The risk prediction model was established based on relevant risk factors screened with LASSO regression. Results A total of 108 patients were involved, including 43 cases (39.81%) with abnormal coagulation dysfunction and 65 cases (60.19%) with normal coagulation function. Cefoperazone/sulbactam related coagulation dysfunction was characterized by prolonged PT and APTT, decreased PTA and increased INR. PT, PTA and INR were susceptible to cefoperazone/sulbactam and changed significantly, which could be used as sensitive indicators for risk identification. The risk of coagulation dysfunction after medication was positively correlated with APACHE Ⅱ score (OR=1.133, 95%CI: 1.039-1.234), age (OR=1.024, 95%CI: 0.993-1.054), and negatively correlated with PTA (OR=0.959, 95%CI: 0.929-0.989). Conclusions The use of nomogram for risk assessment to identify high-risk groups and strengthen the monitoring of PT, PTA, and APTT can reduce the occurrence of risk events.
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